... transplantation. The range of incidence of chronic graft-versus-host disease in children found in this review was large, from 0% to 46%. Incidence of chronic graft-versus-host disease was influenced by ... (Th2) cells can initiate a response against autoantigens leading to B -cell hyperre-activity and production of autoantibodies, causing target-organ damage, including skin, mucosa, eyes, joints, ... GVHD is initiated, T-cells produce additional proinflammatory cytokines, including tumor necrosis fac-tor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-2, which in turn attract more T-cells...