... ENHANCING EXPLANATION COHERENCE WITH RHETORICAL STRATEGIES
MARK T. MAYBURY
Rome Air Development Center
Intelligent Interface ... knowledge to
enhance the perspicuity of the explanation.
- 169 -
EXPLANATION RHETORIC
The implemented system, EXPLAN,
exploits models of rhetorical strategies, focus
models, as well as entity-distinguishing ... These
sub -strategies, which p...
... hematopoietic stem ⁄ precursor cells, trans-
duced with only the AF4–MLL transgene, developed
an acute lymphoblastic leukemia within 6 months
[36].
P-TEFb as potential drug target
As outlined above, ... destruction of SMAD3, and thus
interferes with transforming growth factor (TGF)b sig-
naling [44]. In line with this, GSK3 has recently been
identified in a complex with DDX3 and cell...
... allosteric
DNAzyme with dual RNA-cleaving and DNA-cleaving activities is very
challenging. We used an in vitro-selected pistol-like (PL) DNAzyme as a
DNA scaffold for designing a DNAzyme with dual catalytic ... As compared with PL DNAzyme, DRc DNA-
zyme function seemed to have decreased sensitivity to
the reaction temperature. DRc DNAzyme exhibited a
broad functional range for temperatu...
... nucleolin, with the binding site
located within the C-terminal RGG domain of nucleo-
lin [52]. We preincubated sections of E10 chick
embryos with 0.5 mgÆmL
)1
lactoferrin. This preincuba-
tion with ... 100] were diluted in growth
medium and incubated with the cells for 30 min at 4 °C.
Cells were then washed three times with cold NaCl ⁄ P
i
and
fixed with 4% paraformaldehyde for 15...
... cisplatin DNA treatment
correlated with the occurrence of sequence motifs forming stable bifunc-
tional adducts with the drug (namely, GG and AG doublets) within the
target sites. Binding of ... protein with cer-
tain response elements can be controlled by changes in
DNA topology inducing formation of non-B DNA
structures within the binding sites [11,12]. Interactions
of p53 with DNA...
... Wilmington, MA,
USA). Livers were perfused with Hanks buffer supplemen-
ted with collagenase II (Biochrom, Berlin, Germany).
Experiments were carried out in accordance with the
German Animal Welfare Act ... (Biochrom) supple-
mented with l-glutamine and dexamethasone. Cells were
starved for 5 h in Williams’ medium E supplemented with
l-glutamine. Each dish was stimulated with 40 n...
... the
RDDT
R
strain were measured with all recombinant pro-
teins, namely testosterone hydroxylation and DDT meta-
bolism. Testosterone was hydroxylated at the 2b position
with little quantitative variation ... 271, 1250–1257 (2004) Ó FEBS 2004 doi:10.1111/j.1432-1033.2004.04025.x
relation with xenobiotic metabolism or with metabolism of
endogenous compounds [24,25]. Models for CYP51 we...
... mottling
virus (TVMV) are members of the family Potyviridae,
a subdivision of the picornavirus super group. About
200 potyviruses have been identified to date. Potyvirus
RNA genomes are about 10 kb in ... proteases. Enzyme residues are shown
with capped sticks, and the P4 residue of
the substrate is shown with ball and stick
representation.
Comparison of two potyvirus proteases J. To
¨
zse...
... weakly
pareto-optimal if there is no other hypothesis that
improves all the metrics; a hypothesis is pareto-
optimal if there is no other hypothesis that improves
at least one metric without detriment to other ... A hypothesis
h
∗
∈ L is weakly pareto-optimal iff there is no other
hypothesis h ∈ L such that M(h) > M (h
∗
).
Weakly pareto-optimal points are a superset of
pareto-optimal poin...
... 4-ddma-atc and rescreened for
induction with 0.4 lm atc and without inducer on
MacConkey agar plates. We screened 17 600 colonies
with mutations in helix a1, 29 840 with mutations in
helix a4 and 3900 ... repres-
sion. TetR
i2
-E15A L17V shows repression to 12.5%
with 4-ddma-atc and to 58% with atc, thus showing
only fivefold improved repression with 4-ddma-atc over
atc. A similar...