Tài liệu Báo cáo khoa học: "PLAN REVISION IN PERSON-MACHINE DIALOGUE" docx
... (sentence 14). In the case of inconsistent values (sentence 20), a subplan is inserted for explaining why the value is inconsistent and asking the user to change something in order to correct ... dialogues, we distinguish between task level goals and plans (e.g., investing, traveling), and communicative level inten- tions and speech acts (e.g., explaining, re- questing informatio...
Ngày tải lên: 22/02/2014, 10:20
... subjects of finite verbs have nomina- tive case, so in the FINITE class frame we stipulate (CASE NOMINATIVE) for the subject. If we used the complete mode of inheritance in determining the case ... outputs is an instance; each rule copies idiosyncratic information from the input frame while avoiding copy- ing information which can still be inherited; each rule takes as input a sing...
Ngày tải lên: 21/02/2014, 20:20
... of interest for any rational user. All dominant options represent some tradeoff, but depending on the user’s interest, some of them are more interest- ing tradeoffs than others. Pruning dominated ... for cooperative response generation in information dialogues. In AAAI/IAAI 1999 pp. 148–155. M. Steedman 2000. Information structure and the syntax- phonology interface. In Linguistic Inqui...
Ngày tải lên: 22/02/2014, 02:20
Tài liệu Báo cáo khoa học: Transient DNA ⁄ RNA-protein interactions docx
... investing time and effort in preparing and analyzing the full-length protein can be extremely rewarding, as shown by the information obtained with the tumor suppressor protein BRCA2 and its interac- tion ... structure facilitating protein bind- ing (indirect) and specific amino acid–base contacts (direct). A recent examination of proteinÆnucleic acid structures has shown how minor groove nar...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... CIP1 is involved in gefitinib-induced growth inhibition in HNSCC [58]. Another group of cell-cycle regulatory molecules – those of the INK4 family – has also been implicated in gefitinib-induced inhibition ... consists of p15 INK4b , p16 INK4a , p18 INK4c and p19 INK4d . AG1478, which, like gefitinib and erlotinib, acts as a specific inhibitor of the EGFR tyrosine kinase, has been shown to...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: How disorder influences order and vice versa – mutual effects in fusion proteins containing an intrinsically disordered and a globular protein docx
... (2005) The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct sites and remains predominantly ... (2008) Mapping alpha-helical induced folding within the intrinsically dis- ordered C-terminal domain of the measles virus nucleo- protein by site-directed spin-labeling EPR spectroscopy. Protein...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf
... are linked to accessory proteins (e.g. zonula occludens proteins and cingulin), forging a connection to the actin cytoskeletons of endothelial cells [8]. Occlu- din is an 65 kDa phosphoprotein ... Claudins are 22 kDa phosphoproteins that are thought to help maintain high transendothelial electrical resistance. Three types of claudins (claudin1 ⁄ 3, claudin5 and claudin12) are found in ....
Ngày tải lên: 18/02/2014, 11:20
Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc
... vascular leaks during the clinical course of brain diseases or during the treatment of brain ischemia using pro-angiogenic medicine. Acknowledgements This work was supported by Grant -in- Aid Special ... stress, resulting in an aggressive phenotype in terms of inva- sion and metastasis in vivo [35]. Late in its clinical course, malignant glioma is known to show extensive cell migratio...
Ngày tải lên: 18/02/2014, 11:20
Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke docx
... for t-PA-induced intracranial bleeding in mouse models of focal stroke [37]. In this model, co-treatment with the broad-spectrum MMP inhibitor GM6001 effectively reduced intracranial bleeding. More recently, ... reinter- preted in the context of angiogenesis in the brain. Is it possible that some of the acute neurovascular events in the brain after stroke represent an endogenous att...
Ngày tải lên: 18/02/2014, 11:20
Tài liệu Báo cáo khoa học: Catabolite repression in Escherichia coli – a comparison of modelling approaches docx
... B do- mains being part of the phosphorylation chain and the EIIC domain representing the membrane domain. As all components of the PTS, depending on their phos- phorylation status, can interact ... transferred to the incoming glucose. The degrees of phosphorylation of the various PTS proteins represent starting points for a number of signal transduction pathways. A. Kremling et al. Modelling...
Ngày tải lên: 18/02/2014, 13:20