Tài liệu Báo cáo khoa học: "STRING-TREE CORRESPONDENCE GRAMMAR: A DECLARATIVE GRAMMAR FORMALISM FOR DEFINING THE CORRESPONDENCE BETWEEN STRINGS OF TERMS AND TREE STRUCTURES" pdf

... functional state, which initi- ates the translocation of the catalytic domain. Here, the data allowed identification of the core of the pro- tein in the N state and the evolution of the overall structure ... fragments: the A chain corresponding to the catalytic domain (C domain); and the B chain corresponding to the translocation domain (T domain) and t...

Ngày tải lên: 16/02/2014, 09:20

... (RSC-09-245-01-DMC) from the American Can- cer Society and by NIH grant number R01CA140522 from the National Cancer Institute (to MSC). We thank Venkat Dharmarajan for a critical reading of this manuscript. ... The Authors Journal compilation ª 2010 FEBS 1841 of cell fate. Leukemias associated with loss -of- function or gain -of- function variants of MLL1 are prime exam- ple...

Ngày tải lên: 16/02/2014, 14:20

... before an apparent increase in absorbance of 0.1 was recorded. The addition of PDI to the assay accelerated the reduc- tion and precipitation of the B-chain significantly, decreasing the lag-phase ... region x between the b¢ and a domains, and a C-terminal acidic extension. The a and a domains contain the CGHC active site motif, and are sufficient alone t...

Ngày tải lên: 16/02/2014, 14:20

... [44], and they express mathemati- cally the fact that the total concentration of each of the four proteins is conserved. In particular, they are: Table 1. The state variables of the original (O) and ... pathway in enteric bacteria regulating the uptake of carbon sources and, in addition, it catalyzes the uptake of glucose. The previous model [8] has 13 state var...

Ngày tải lên: 18/02/2014, 06:20

... MINIREVIEW Pharmacologic chaperoning as a strategy to treat Gaucher disease Zhanqian Yu, Anu R. Sawkar and Jeffery W. Kelly Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps ... H, Ikeda K, Yasuda K, Kato A, Martin OR & Fan J-Q (2000) In vitro inhibition and intracellular enhancement of lysosomal a- galactosidase A activity in Fabry...

Ngày tải lên: 18/02/2014, 16:20

...  4 Da, the decrease of the molecular mass value. The most proba- ble reason for a 2 Da decrease is the formation of an S–S bond; although this was totally unexpected and unprecedented, the top-down ... Neil Kelleher, Harold Scheraga and Klaas van Wyck for valuable discussions, and the General Medical Institute of the National Institutes of Health, GM16609,...

Ngày tải lên: 18/02/2014, 16:20

... immunoblotting and by autoradiography as indicated. (B) The autoradiographic Cdc45 bands were quantified with the program PHORETIX 1D ADVANCED, and depicted in a graph. A B Fig. 7. Calculation of the number ... indicated times for later analyses. After 7 days of serum starvation the majority of T98G and HEF cells reached quiescence, as monitored by the absence of...

Ngày tải lên: 19/02/2014, 00:20

... and characterizing individual mutant proteins, these combinatorial approaches offer the important advantage of simultaneously generating libraries of protein variants, thus allowing a much larger number ... library in half and sort one half against a binding partner and the other half against an expression tag. A comparison of the sequences obtained from these two diff...

Ngày tải lên: 19/02/2014, 12:20

... units. Caspases and inhibitors Caspase substrates and their inhibitors were purchased from Biomol. Ac-DEVD-AMC is a substrate for caspases 3 and 7; Ac-YVAD-AMC is a substrate for caspase 1; Ac-IETD-AMC ... is a substrate for caspase 8 and 10; Ac-LEHD-AMC is a substrate for caspases 2, 4, 5 and 9. Ac-DVPD-AMC, Ac-DPSD-AMC and Ac-ESQD-AMC are tetra peptide substrates...

Ngày tải lên: 19/02/2014, 13:20

... TAT ATG T Weak 3 aa 2 ⁄ 4 55067 TCA ATG C Weak 58 aa 3 33 39% 60929 60933 60939 GTA ATG C TGC ATG T TCC ATG G G Adequate Weak Adequate 13 aa 33 aa 31 aa 3¢ 76 49% – 4¢ 56 61% 61041 GGA ATG T Adequate ... cells and brain. Table 1. Putative start codons of Hu-K4. Comparison of the optimal translational start site given by Kozak [12] and the putative start co- dons in the Hu-K4 mRN...

Ngày tải lên: 19/02/2014, 17:20