... Ventura1,21Department of Biomedical Sciences, Division of Biochemistry, Laboratory of Cardiovascular Research,2Division of Cell Biology,National Institute of Biostructures and Biosystems, and3Department of ... activation is mediated, at least in part, by G-protein coupled receptors (GPCRs), stimulation of membrane phospholipid hydrolysis, and activation of thediacylglycerol sensitive isoforms of protein ... theactivation of ERK by GPCRs closely parallels thatemployed by RTK [33]. On the whole, these observationssuggest that the inhibitory effect elicited by NAMI-A on ERK signaling might have occurred by...