... possible only by the proline in the cis confor-mation.Indirectly, we have confirmed that proline isomeriza-tion is at the root of the slow conformational changecoupled to tetramerization by measuring ... Mos-lehi JJ, Serpell L, Arnsdorf MF & Lindquist SL (2000)Nucleated conformational conversion and the replica-tion of conformational information by a prion determi-nant. Science 289, 1317–1321.99 ... double-concerted fibrillation; IDPs,intrinsically disordered proteins; MDC, monomer-directed conversion; NCC, nucleated conformational conversion; NDP, nucleation-dependent polymerization; NP,...