Tài liệu Báo cáo khoa học: "Syntactic and Semantic Kernels for Short Text Pair Categorization" docx

... 2009.c2009 Association for Computational LinguisticsSyntactic and Semantic Kernels for Short Text Pair CategorizationAlessandro MoschittiDepartment of Computer Science and EngineeringUniversity ... kernel for the repre-sentation of shallow semantic informationalong with a comprehensive study on ker-nel methods for the exploitation of syntac-tic /semantic structures for short text pair categorization. ... studythe impact of the above kernels as well as se-quence kernels based on words and Part of SpeechTags and tree kernels for the classiﬁcation of ques-tion/answer text pairs.4.1 Experimental SetupThe...

Tài liệu Báo cáo khoa học: "Syntactic and Semantic Transfer with F-Structures*" pptx

... transfer is as simple and straightfor- ward as possible. On the other hand, they need to encode sufficiently fine-grained information to steer transfer. Furthermore, target and source representations ... quasi- semantic representation for transfer and gener- ation. The translation between f-structures and terms is based on the correspondence between directed graphs representing f-structures and ... can be converted into sets of terms and vice versa} F-structure 1For motivation why we prefer term representations PRED features and their " ;semantic form" values are given special...

Tài liệu Báo cáo khoa học: Applications and trends in systems biology in biochemistry docx

... NADH,H+ and therefore balancing for theseconditions is only possible with onepathway converting NADH,H+toNADPH,H+, the only form regulatedby photosynthesis in Arthrospira.This is performed ... (SBML): a medium for representa-tion and exchange of biochemical network models.Bioinformatics 19, 524–531.48 Lloyd CM, Halstead MDB & Nielsen PF (2004)CellML: its future, present and past. ... 564,63–68.13 Carbohydrate,formaldehydeMethylobacteriumextorquensResults demonstrate the role ofredundancy in formaldehydemetabolism and uncover a newparadigm for coping with toxic,high-ﬂux...

Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf

... H4-K5, K8 and K12 acetylation [136–138]. In yeast, this group ismade up of NuA4 and Piccolo NuA4 which both uti-lize Esa1 as the HAT, and Esa1 was found to be essen-tial for H4-K5, K8 and K12 ... Tip60which forms a NuA4-like complex, and HBO1 whichmore closely resembles yeast Piccolo NuA4 [138]. Inmammals, it is HBO1 and not Tip60 which is responsi-ble for the bulk of the global H4-K5, K8 and ... enriched atTATA-less promoters and may therefore play a role ofmaintaining this class of promoter in an open confor-mation [196].Many promoters contain CG islands that formunstable nucleosomesThe...

Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx

... tumors and cell lines, miR-17-5p and miR-20a are induced in a manner that dependson cyclin D1 and repress the expression of cyclin D1.Hence, miR-17-5p ⁄ 20a and cyclin D1 form a feedbackloop and ... cross-linking and immunoprecipitation also provides genome-wide inter-action maps for miRNAs and mRNAs, which enablescomprehensive identiﬁcation of miRNA targets [60].By integrating mRNA and miRNA ... miRNAs and cell signalingFEBS Journal 278 (2011) 1610–1618 ª 2011 The Authors Journal compilation ª 2011 FEBS 1615(NIBIO) (G.T.); and in part by KAKENHI, Grant-in-Aid for Japan Society for the...

Tài liệu Báo cáo khoa học: MicroRNAs and epigenetics doc

... cardiovasculardiseases [12] and carcinogenesis [13]. The biogenesis and RNAi functions of miRNA (i.e. how miRNAs aregenerated and processed into a mature form, and howthey regulate gene expression) ... ATP-dependent manner [20]. Next, onestrand (the passenger strand) of the miRNA isremoved from the RLC, whereas the other strand (theguide strand) remains in the complex to form amature RNA-induced silencer ... the RISC complex, and degrades themby the SKI complex and XRN1 [21]. For partiallycomplementary targets, the RISC complex decaps and deadenylates target mRNAs via the DCP1-DCP2 and CAF1-CCR4-NOT...

Tài liệu Báo cáo khoa học: MicroRNAs and cardiovascular diseases ppt

... miR-33 and statins may be a usefultherapeutic strategy for raising HDL and lowering lowdensity lipoprotein levels, especially for metabolicsyndrome subjects.K. Ono et al. MicroRNAs and cardiovascular ... pathological conditions. Gain- and loss-of-func-tion studies using in vitro and in vivo models have revealed distinct roles for speciﬁc miRNAs in cardiovascular development and physiological func-tion. ... groups have disruptedthe gene for Dicer in mice and reported that the lossof Dicer resulted in embryonic lethality at embryonicday (E)7.5, before body axis formation, as a result ofeither...

Tài liệu Báo cáo khoa học: Functional and structural analyses of N-acylsulfonamidelinked dinucleoside inhibitors of RNase A ppt

... alternativeconformations.The pseudorotation angles for the uridine of N-acyl-sulfonamide 7 were found in both the C3¢-endo (N)conformation and the O4¢-endo conformation, whereasthe C3¢-endo conformation ... [41] and UpA (PDB code 11ba) [42]. The structure ofN-acylsulfonamide 7 was reﬁned with full occupancy,except for the alternative conformations observed for the N-acylsulfonamidyl group and the ... probes are useful for both studying and controlling the functionsof enzymes and other proteins. The most useful probes have high afﬁnity for their target, along with small size and resistance to...

Tài liệu Báo cáo khoa học: Active and regulatory sites of cytosolic 5¢-nucleotidase doc

... activation site (R144, N154, I152) and three in thesecond (F127, M436 and H428), and found that Ap4A and ADP interactwith the same site, but the sites for ATP and BPG remain uncertain. Thestructural ... effector sites, one for ATP, one for ADP and one for BPG [5,12]. On thebasis of the results obtained from crystallization of atruncated form of cN-II [11], we constructed pointmutants for a number ... in particular thenumber and location of the interaction sites for theactivators and inhibitors, the relationship betweenactivity and enzyme oligomerization state, and, ﬁnally,the amino acid...

Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

... HPRT and hypoxanthine. (C) PRTFDC1 and guanine. (D) HPRT and guanine.Table 2. Km and Vmaxvalues for Hx and G in the presence of 1 mM PRPP, determined using the DE-81 ﬁlter paper assay and ... observed for hypoxanthine and guanine (Table 1). These resultsimply that PRPP is required for the nucleobases tobind. For comparison the DSLS thermal melt assaywas run for HPRT but, unfortunately ... thermal-meltassay. PRPP, IMP and GMP were the top hits and therefore were identiﬁed as potential substrates, prod-ucts or regulatory ligands for PRTFDC1. The catalyticefﬁciency and substrate speciﬁcity...

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