... aPlasmodium falciparum cysteine proteinase. J Clin Invest88, 1467–1472.38 deDominguez NDG & Rosenthal PJ (1996) Cysteineproteinase inhibitors block early steps in hemoglobindegradation by cultured ... agents, like those interfering withhemozoin polymerization in the vacuole (chloroquine,quinine, mefloquine and other alkaloids), the dihydro-folate pathway (pyrimethamine, sulphadoxine, progua-nil), ... peptideprocessing activity in the apicoplast [48]; the mito-chondrial processing peptidases (PFE1155c, PFI1625c),or insulysin and pitrilysin [32], possibly involved in theprocessing of apicoplast protein...