Tài liệu Báo cáo khoa học: "Effect of Cross-Language IR in Bilingual Lexicon Acquisition from Comparable Corpora" pot

... performance of ac-quiring bilingual term correspondences from com-parable corpora, i.e., in reducing useless bilingual term pairs and in increasing the estimated confi-dence of useful bilingual ... 146 bilingual term pairs with an existing bilingual lexicon (Eijiro Ver.37, 850,000 entries,http://member.nifty.ne.jp/eijiro4where 86 of them (almost 60%) are not included in the existing bilingual ... usefulness of cross-language retrieval of relevant texts in ac-quisition of bilingual term correspondences.4.3.2 Rates of Containing Correct Bilingual Term PairsNext, we evaluate the following rate of...

Tài liệu Báo cáo khoa học: Effect of siRNA terminal mismatches on TRBP and Dicer binding and silencing efﬁcacy pdf

... loading complex proteinsHIV transactivating response RNA-binding protein and Dicer in H1299cytoplasmic extracts. Binding of siRNA and the transactivating responseRNA-binding protein was signiﬁcantly ... in their terminal hybridizationstabilities compared to non-functional siRNAs [15–17]. In Drosophila, the protein R2D2 binds to the more sta-ble end of the siRNA duplex and directs binding of Dicer-2 ... preference forbinding of fully matched siRNAs over siRNAs with aterminal mismatch. These results indicate that recogni-tion and binding of the siRNAs by Dicer and TRBP in cells might involve ATP...

Tài liệu Báo cáo khoa học: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr docx

... Tanner [18]. Treatment of PhyAsr with100 lm H2O2resulted in 33% of the enzyme beinginactivated after 10 min of treatment and 65% beinginactivated after 30 min. Incubation of the enzyme forup ... P-loop main chain (starting at theresidue prior to the catalytic cysteine and ending afterthe conserved arginine) resulted in rmsd values of < 0.75 A˚(supplementary Table S3). In 23 of thesePTPs, ... further inac-tivate the enzyme. Incubation of PhyAsr with 1 mmH2O2resulted in an 85% decrease in activity after10 min and a loss of approximately 95% of its activityafter 30 min. Treatment of...

Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx

... November2004)doi:10.1111/j.1742-4658.2004.04482.xThe role of DNase I hypersensitive sites (DHSs) in transcription of the Bcell-speciﬁc Ig-b gene and in maintenance of active chromatin state in theIg-b locus were examined. A total of 10 DHSs ... transcription of the Ig-b genebut not required for the maintenance of active chromatin state in the Ig-blocus. Thus, epigenetic factors required for the maintenance of the activechromatin state ... acetylation of H3 and H4histones, and the remaining DHSs in the deleted cellswere examined to determine the roles of these DHSson the transcription of Ig-b gene and on the mainten-ance of the...

Tài liệu Báo cáo khoa học: Effect of gadolinium on the ryanodine receptor/ sarcoplasmic reticulum calcium release channel of skeletal muscle docx

... muscle. In the[3H]ryanodine binding assay, 5 lm Gd3+increased the Kd of the [3H]ry-anodine binding of the vesicles from 33.8 nm to 45.6 nm while Bmax, refer-ring to the binding capacity, ... Gadolinium dependence of the ryanodine binding of thechannel. Ryanodine binding in the presence of 18 nM [3H]ryanodinewere determined at various gadolinium concentrations. Solid linerepresents ... thevisualization of the protein composition of the fractions.Ryanodine-bindingRyanodine-binding assays were carried out using [3H]ry-anodine in a medium having the composition of 1 m NaCl,S....

Tài liệu Báo cáo khoa học: Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites pdf

... 2).Increasing the concentration of the NC/p1 substrate abovethe Kmresulted in a decreased velocity, suggesting thepossibility of increased nonproductive binding at thesubstrate binding ... Gagmutations against two BILA inhibitors [23], and in patientstreated with ritonavir [22] or indinavir [24]. Based on clinicalstudies, the resistant Gag mutations may occur early in PRinhibitor ... appearing in other HIV-1 virus iso-lates [18] are indicated under the sequence of HIV-1IIIB, while residuesappearing only in drug resistance are in bold [9–13]. MutationsunderlinedintheFigurealsoappearedindrugresistanceonapar-ticular...

Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

... shown that interactions betweenKCs and endotoxin comprise the initiating event lead-ing to hepatotoxicity in liver injury, including endotox-emia and ischemia ⁄ reperfusion injury [14]. In ourstudies, ... [22]. ROS indirectly reduced the activity of selected isoforms of CYP by inducing phosphorylation of the isoforms [23]. Activated KCs cause oxidativestress on the surrounding tissue, releasing largeamounts ... mediator of lethal sepsis, triggering theproduction of proinﬂammatory cytokines and liverinjury [13].Therefore, the present study aimed to elucidate therole of KCs in the regulation of CYP isoform...

Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf

... long-chain saturatedfatty acids (SFAs) led to increased expression of proin-ﬂammatory cytokines, inhibition of insulin signaling,induction of endoplasmic reticulum (ER) stress, andpromotion of ... elevations in theexpression of activating transcription factor 4 (ATF4)and of CCAAT⁄ enhancer-binding protein homologousprotein (CHOP) proteins downstream of eIF2a wereobserved (Fig. 4A), indicating ... celltoxicity. These ﬁndings are in agreement with previousobservations from the Schaffer group, indicatingincreased incorporation of palmitate (16:0) into theTAG pool only in the presence of oleate [18].The...

Tài liệu Báo cáo khoa học: Role of ceramide kinase in peroxisome proliferatoractivated receptor beta-induced cell survival of mouse keratinocytes ppt

... in skin barrier disruption(Fig. 1A). PPARb mRNA expression was determined in keratinocytes isolated from the epidermal layer of these skins, and was found to be signiﬁcantly increased in skin ... culturedhuman keratinocytes [14]. In this study, we examined the interaction betweenCerK and PPARb, and its role in regulating keratino-cyte survival. We report that in a mouse keratinocytecell line upregulation ... upregulation of CERK expression by activa-tion of PPARb results in a decrease in intracellularCer levels and enhancement of cell survival.ResultsSkin barrier disruption in hairless mice inducesmRNA...

Tài liệu Báo cáo khoa học: Motion of the Ca2+ -pump captured ppt

... (long-distance move-ment of the N-domain and rotational motion of theA-domain) of SERCA during the ATP-mediated iontransport reaction [14,16–19].The single line scanning method [8,15], in which anAFM ... Ca2+wasmeasured in the single line FSAFM images, andFig. 1. Single-molecule imaging of SERCA dynamics in the presence of nucleotide and Ca2+. (A) Time-lapse sequence FSAFM images of SERCA in the SR ... concentration in the range from 10 nm to 100 lm, indicating that the up–down confor-mational change of SERCA (i.e. the reaction afterATP binding) did not require further ATP binding orhydrolysis,...

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