Tài liệu Báo cáo khoa học: "NATURAL-LANGUAGE ACCESS TO DATABASES--THEORETICAL/TECHNICAL ISSUES" docx

... transcriptional activator CAP [16], and the landscape of free DNA includes transient confor- mations whose relevance still needs to be investigated [17]. Many transcription factors bind to thousands of places ... protein regulator of chromosome condensation 1 (RCC1, also known as RanGEF or Ran guanine exchange factor), with implications for nuclear transport and mitosis. This structure is...

Ngày tải lên: 14/02/2014, 19:20

... HCT116 cells to proteasome inhibitors. Int J Oncol 24, 935–941. 19 Falchuk KH, Goetzl EJ & Kulka JP (1970) Respiratory gases of synovial fluids. An approach to synovial tissue circulatory–metabolic ... [2,3]. Tumour necrosis factor-related apoptosis-inducing ligands (TRAILs) are type II transmembrane mole- cules that trigger the apoptotic signal cascade by bind- ing to cognate recept...

Ngày tải lên: 18/02/2014, 14:20

... binding to this crystallin by ITC and determined the binding constant for the calcium mimic probe. Terbium is believed to bind strongly to calcium-binding sites of proteins compared to calcium due to ... was grown in terrific broth to mid log phase at 37 °C. When the A 600 was between 0.6 and 1.0, isopropyl thio-b-d-galactoside was added to the final concentration of 1 mm to ind...

Ngày tải lên: 18/02/2014, 16:20

... leading to mixtures of modified pro- teins that may differ in function. In order to fully dis- sect the biological role of PTMs and determine precise structure–activity relationships, access to pure ... (EPL) has provided access to larger peptide fragments. Mac- millan et al. have used EPL to construct three well- defined model GlyCAM-1 glycoproteins [33], the first reported modula...

Ngày tải lên: 18/02/2014, 17:20

... storage compartments for a number of pro-death proteins, such as cytochrome c, which are released into the cytoplasm as a consequence of apoptotic signals. The release of these apoptotic factors ... normally found soluble in the cytoplasm, its apoptotic activation includes extensive structural reor- ganization, which facilitates targeting to, and insertion into, the mitochondrial outer membr...

Ngày tải lên: 19/02/2014, 07:20

... receptor’s primary sequence shows stri- king similarities to the somatostatin receptor family, most notably in the transmembrane domains. The pharmacological relatedness of somatostatin receptors is ... receptor was initially considered to only couple Ga q proteins, the receptor seems to be involved in an array of interactions with other signa- ling molecules whose full spectrum remains...

Ngày tải lên: 19/02/2014, 07:20

... than NNN toward Leu, Ser and Arg, and includes only one stop codon). However, the natural repertoire of amino acids is highly restrictive compared to the useful alterations that can be made to small ... long day), we want to be able both to understand what makes proteins ÔtickÕ andtoengineer proteins with native-like properties. In this review we discuss combinatorial approaches towar...

Ngày tải lên: 19/02/2014, 12:20

... on the interaction of a-conotoxins with neuronal nicotinic receptors in light of our new understanding of the receptor structure. Computational tools are expected to reveal the molecular recognition mechanisms ... muscle subtype, thanks to the large amount of the receptor obtained from the electric organ of the Torpedo marmorata ray and availability of selective pharmacological tools like...

Ngày tải lên: 19/02/2014, 12:20

... is clear to the reader. In all of these examples it is necessary to un- derstand the complete system in order to pro- gram a machine to recognize the complex of features and to translate ... relationships of one word to another in patterns. The third type — the ability of the program to determine the syn- tactic function of each word — is basic to the others. It is b...

Ngày tải lên: 19/02/2014, 19:20

... chunk -to- string model into two models: a loose model (Section 2.1) which is more similar to the hierarchical phrase-based model and a tight model (Section 2.2) which is more similar to the tree -to- string model. The ... hierarchical chunk -to- string model into two models: a loose model which is more similar to the hierarchical phrase-based model and a tight model which is more simil...

Ngày tải lên: 19/02/2014, 19:20