Tài liệu Báo cáo khoa học: "NATURAL-LANGUAGE ACCESS TO DATABASES--THEORETICAL/TECHNICAL ISSUES" docx
Tài liệu Báo cáo khoa học: Transient DNA ⁄ RNA-protein interactions docx
... transcriptional activator CAP [16], and
the landscape of free DNA includes transient confor-
mations whose relevance still needs to be investigated
[17]. Many transcription factors bind to thousands of
places ... protein
regulator of chromosome condensation 1 (RCC1, also
known as RanGEF or Ran guanine exchange factor),
with implications for nuclear transport and mitosis.
This structure is...
Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf
... HCT116 cells to proteasome inhibitors. Int J
Oncol 24, 935–941.
19 Falchuk KH, Goetzl EJ & Kulka JP (1970) Respiratory
gases of synovial fluids. An approach to synovial tissue
circulatory–metabolic ... [2,3].
Tumour necrosis factor-related apoptosis-inducing
ligands (TRAILs) are type II transmembrane mole-
cules that trigger the apoptotic signal cascade by bind-
ing to cognate recept...
Tài liệu Báo cáo khoa học: Calcium-binding to lens bB2- and bA3-crystallins suggests that all b-crystallins are calcium-binding proteins pptx
... binding to this crystallin by ITC and
determined the binding constant for the calcium
mimic probe. Terbium is believed to bind strongly to
calcium-binding sites of proteins compared to calcium
due to ... was grown in terrific
broth to mid log phase at 37 °C. When the A
600
was
between 0.6 and 1.0, isopropyl thio-b-d-galactoside was
added to the final concentration of 1 mm to ind...
Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modifications ppt
... leading to mixtures of modified pro-
teins that may differ in function. In order to fully dis-
sect the biological role of PTMs and determine precise
structure–activity relationships, access to pure ... (EPL)
has provided access to larger peptide fragments. Mac-
millan et al. have used EPL to construct three well-
defined model GlyCAM-1 glycoproteins [33], the first
reported modula...
Tài liệu Báo cáo khoa học: Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores pdf
... storage compartments for a
number of pro-death proteins, such as cytochrome c,
which are released into the cytoplasm as a consequence
of apoptotic signals. The release of these apoptotic
factors ... normally found soluble in the cytoplasm, its
apoptotic activation includes extensive structural reor-
ganization, which facilitates targeting to, and insertion
into, the mitochondrial outer membr...
Tài liệu Báo cáo khoa học: From heart to mind The urotensin II system and its evolving neurophysiological role ppt
... receptor’s primary sequence shows stri-
king similarities to the somatostatin receptor family,
most notably in the transmembrane domains. The
pharmacological relatedness of somatostatin receptors
is ... receptor was initially considered to
only couple Ga
q
proteins, the receptor seems to be
involved in an array of interactions with other signa-
ling molecules whose full spectrum remains...
Tài liệu Báo cáo khoa học: Combinatorial approaches to protein stability and structure pdf
... than NNN
toward Leu, Ser and Arg, and includes only one stop
codon). However, the natural repertoire of amino acids is
highly restrictive compared to the useful alterations that can
be made to small ... long day), we want to be able both
to understand what makes proteins ÔtickÕ andtoengineer
proteins with native-like properties.
In this review we discuss combinatorial approaches
towar...
Tài liệu Báo cáo khoa học: Computational approaches to understand a-conotoxin interactions at neuronal nicotinic receptors doc
... on the interaction of
a-conotoxins with neuronal nicotinic receptors in light of our
new understanding of the receptor structure. Computational
tools are expected to reveal the molecular recognition
mechanisms ... muscle
subtype, thanks to the large amount of the receptor
obtained from the electric organ of the Torpedo marmorata
ray and availability of selective pharmacological tools like...
Tài liệu Báo cáo khoa học: "A Framework for Syntactic Translation" docx
... is
clear to the reader.
In all of these examples it is necessary to un-
derstand the complete system in order to pro-
gram a machine to recognize the complex of
features and to translate ... relationships of one
word to another in patterns. The third type —
the ability of the program to determine the syn-
tactic function of each word — is basic to the
others. It is b...
Tài liệu Báo cáo khoa học: "Hierarchical Chunk-to-String Translation" ppt
... chunk -to- string
model into two models: a loose model (Section
2.1) which is more similar to the hierarchical
phrase-based model and a tight model (Section
2.2) which is more similar to the tree -to- string
model.
The ... hierarchical chunk -to- string
model into two models: a loose model which is more
similar to the hierarchical phrase-based model and
a tight model which is more simil...