... explanation for the increased inflammation asso-ciated with aging, and may be a pathway that links agingwith an increased risk of atherothrombosis.TGF -a, a member of the EGF family, is a potent ... characterized by an increase in proinflam-matory mediators present in serum [1,2]. Changes in T-cell homeostasis with aging are associated with a decline in immunity and increa sed inflammation. ... colony-stimulating factor (GM-CSF),interferon -a2 (IFN -a2 ), INF-g, IL-10, IL-15, IL-17, IL-1b,IL-2,IL-6,IL-8,INF-g inducible protein 10 (IP-10),monocyte chemoattractant protein-1 (MCP-1), macro-phageinflammatoryprotein-1b...