Tài liệu Báo cáo khoa học: Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits ppt

... CK2 (aa’b 2 ). Ó FEBS 20 02 CK2-mediated phosphorylation of ENaC (Eur. J. Biochem. 26 9) 4555 and the identification of cytosolic fractions that incorporate 32 P into the C termini of b and cENaC ... Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits Haikun Shi 1 , Carol Asher 1 , Yuval Yung 2 , Lu...

Ngày tải lên: 21/02/2014, 03:20

... (6). All of the subgraphs in G raphs (5) and (6) contribute the following 3! terms to the coefficient a 3 : a 3 ¼ðÀ1Þ 3 ðb 11 b 22 b 33 þ b 21 b 13 b 32 þ b 31 b 12 b 23 À b 11 b 23 b 32 À b 22 b 13 b 31 À ... combination do not touch each other). The value (the sign) of a cycle is the product of the values (the signs) of its steps. The sign o f the...

Ngày tải lên: 19/02/2014, 16:20

... In all other cases, go to the step for a middle. Here, P1 and P2 denote the start and end positions of an error-block, and L denotes the length of the input string. Step 2: Take the string ... evaluated the following two factors before and after correction: (1) the counting of errors, and (2) the effectiveness of the method in understanding the...

Ngày tải lên: 20/02/2014, 18:20

... against the existence of the complex and channeling of metabolites [10,11]. Thus, the existence of the com- plex has not been universally accepted. In addition to the cytoplasmic compartment, GAPDH and ... in the presence of citrine–GAPDH by energy transfer (Fig. 2B). Short and long lifetimes, s 1 and s 2 , were reduced to 1.06 and 3.13 ns, respectively. In...

Ngày tải lên: 16/02/2014, 09:20

... C (20 02) Joining the cell survival squad: an emerging role for protein kinase CK2. Trends Cell Biol 12, 22 6 23 0. 3 Meggio F & Pinna LA (20 03) One-thousand -and- one substrates of protein kinase ... them we identi- fied Cka2p, one of the two a subunits of protein kinase CK2 using this approach, however, we did not recover the other a subunit (Cka1p) or any of the...

Ngày tải lên: 18/02/2014, 16:20

... Cohen’s discovery of the ‘tooth-lid factor’ led to the identifica- tion of the genetic causes of certain types of human cancers, and to the genetic classification of a variety of tumors of apparently the same ... molecules and lead to the evasion of apoptosis, to proliferation, to invasion and to metas- tases, all of which are important for the...

Ngày tải lên: 16/02/2014, 09:20

... inhibitors of the tyrosine kinase activity of EGFR (EGFR-TKIs), gefiti- nib and erlotinib, compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor ... with standard cytotoxic chemotherapy for advanced NSCLC. As the data Fig. 2. In the wild-type EGFR, ligand binding to EGFR leads to receptor dimerization, autophosphory...

Ngày tải lên: 16/02/2014, 09:20

... of the core of the pro- tein in the N state and the evolution of the overall structure of the protein in the MG state. This degree of resolution is unprecedented for the T domain of the diphtheria ... regardless of the experimental conditions, such as peptide 23 0 -23 6 (the loop between helices TH2 and TH3; Fig. 3B). This revealed the regions of t...

Ngày tải lên: 16/02/2014, 09:20

... results in the establishment of a unique gene-expression signature that is further enhanced by the presence of the HoxA9 protein [20 ]. Men1 binds directly to the N-terminus of MLL fusions [22 ] and was ... ability Role of MLL in human malignancies R. Marschalek 1 824 FEBS Journal 27 7 (20 10) 1 822 –1831 ª 20 10 The Author Journal compilation ª 20 10 FEBS to bind...

Ngày tải lên: 16/02/2014, 14:20

... [5–8] as effectors to control the catalytic activity of the DNAymes; engineering DNA- zyme-based sensors for Mg 2+ [9,10], Cu 2+ [11], Hg 2+ [ 12, 13], Pb 2+ [14], and UO 2 2+ [15]; and constructing molecular ... Other metal ions, including Mg 2+ ,Ca 2+ ,Mn 2+ ,Co 2+ ,Ni 2+ ,Cd 2+ ,Zn 2+ , and Ba 2+ , failed to facilitate the cleavage activity. The...

Ngày tải lên: 16/02/2014, 15:20