Tài liệu Báo cáo khoa học: The crystal structure of coenzyme B12-dependent glycerol dehydratase in complex with cobalamin and propane-1,2-diol pptx

... inactive and serves as an inhibitor for diol and glycerol dehydratases [57]. Overall structure of glycerol dehydratase in complex with cobalamin and propane-1,2-diol The crystal structure of glycerol ... to those in the diol dehydratase- bound cobalamins (2.9–5.1°) [9,10]. Figure 4C indicates the comparison of the position of the a-acetamide...

Ngày tải lên: 21/02/2014, 03:20

... representation of the overall structure of hACMSD. The (a ⁄ b) 8 barrel domain is colored in light blue and the ACMSD- specific small insertion domain in blue. The DHAP molecule and the protein residues involved ... stereochemistry of the model has been assessed using the program procheck [23]. Ninety per cent of the residues fall in the most favoured regi...

Ngày tải lên: 18/02/2014, 06:20

... -2 and -3. These acti- vating E2Fs cooperate with NF-Y proteins binding to CCAAT-boxes and with Myb proteins associating with a distal Myb site in activating the Cdc2 promoter. Binding of the ... proteins with the promoter. E2F4 binding during the cell cycle coincides with the binding of p107 or p130 [61,85]. Another E2F site distal to the E2F ⁄ CDE acts as an...

Ngày tải lên: 16/02/2014, 09:20

... literature: the dominant polymorph a-chitin (antiparallel packing of the chitin chains); b-chitin (parallel packing of the chitin chains); and the minor polymorph c-chitin (mixture of parallel and antiparallel ... b-chitin. These results show the general importance of chitin-binding proteins in chitin turnover, and provide the first example of a family 33 chitin-b...

Ngày tải lên: 18/02/2014, 08:20

... role in building the Greek key structure and in designing the metal binding site and the active cavity of the system. The analysis of the H-bonds in the present structure has been carried out with MOLMOL program ... regions of the protein: at the interface between the two subunits (mainly in loop IV and b 8), in the odd loops and at the co...

Ngày tải lên: 21/02/2014, 03:20

... conformers. The case of the nystatin A1 is interesting regarding its interaction with the sterols and its incorporation into membranes. Unlike to filipin III, a polyene antibiotic belonging to the group of ... polyenes are certainly the important elements contributing to the high structural order found in the models of pimaricin, rimocidin, candidin and vacidin A....

Ngày tải lên: 21/02/2014, 03:20

... organism. The structure reveals an intimate association between the TPR motifs and the rest of the protein, showing how the TPR par- ticipates in the overall fold. Until now, many of the TPR-containing ... FEBS the full-length HOP, they act to facilitate the assembly of multichaperone regulatory complexes. The struc- tural independence of these TPR domains,...

Ngày tải lên: 07/03/2014, 16:20

... of the precise residues and interac- tions involved in the NTD–CTD interface [46]. Most of these involve side chains from helix 8 of the CTD which pack against the N-terminal end of helix 4 of the ... of the NTD of a neighboring subunit in the hexamer. Additional contacts involve helix 11 of the CTD and the C-terminal end of helix 7 of the NTD...

Ngày tải lên: 18/02/2014, 06:20

... of both the CAI peptide and a-helix 9 of CTD during formation of the peptide– protein and protein–protein complexes. These NMR experiments also allowed the determina- tion of the CTD binding site. ... a kink at Thr188. The two addi- tional aromatic residues in each monomer, Tyr164 and Fig. 1. Structure of the CTD dimer. X-ray structure of CTD showing the...

Ngày tải lên: 18/02/2014, 06:20

... monitoring of the interactions of transforming growth factor-b (TGF-b) isoforms with latency-associated protein and the ectodomains of the TGF-b type II and III receptors reveals different kinetic ... demonstrate binding of proBMP-2 to the ECD of BMPR-IA. Interaction of BMP-2 (A) and proBMP-2 (B) with immobilized ECD of BMPR-IA. Interaction of BMP-2 (C) and...

Ngày tải lên: 18/02/2014, 06:20