Tài liệu Báo cáo khoa học: Solution NMR structure of five representative glycosylated polyene macrolide antibiotics with a sterol-dependent antifungal activity doc

... Solution NMR structure of five representative glycosylated polyene macrolide antibiotics with a sterol-dependent antifungal activity Laurent Volpon and Jean-Marc Lancelin Laboratoire de ... antibiotics, as nystatins and amphotericins, are amphiphilic structures known to exert antifungal activity by disrupting the fungal cell membrane, leading to leakage of...

Ngày tải lên: 21/02/2014, 03:20

... results of a phase II clinical trial with an altered peptide ligand. Nat Med 6, 1167–1175. 22 Tselios T, Daliani I, Deraos S, Thymianou S, Matsou- kas E, Troganis A, Gerothanassis I, Mouzaki A, Mav- romoustakos ... high relaxation with 5-DSA have relatively lower relaxation because of the presence of Fe 3+ . The apparent fast relaxation of V7¢ in the presence of both paramag...

Ngày tải lên: 19/02/2014, 07:20

... nonoxidative decarboxylation catalysed by a- amino-b-carboxymuconate-e-semialdehyde decarbox- ylase. J Am Chem Soc 129, 9278–9279. 20 Fukuoka SI, Ishiguro K, Yanagihara K, Tanabe A, Egashira Y, Sanada ... Walker AL, Iwaki H, Hasegawa Y & Liu A (2005) Kinetic and spectroscopic characterization of ACMSD from Pseudomonas fluorescens reveals a penta- coordinate mononuclear metallocofa...

Ngày tải lên: 18/02/2014, 06:20

... linked to formation of an iron-peroxy adduct prone to fragmen- tation [266]. A similar p aradigm also appears to a pply to the final step in aromatase (CYP19)-catalyzed biotransforma- tion of androgens ... 11–813. 119. Wada, A. , Ogo, S., Watanabe, Y., Mukai, M., Kitagawa, T., Jitsukawa, K., Masuda, H. & Einaga, H. (1999) Synthesis and characterization of novel alkylperoxo m ono...

Ngày tải lên: 19/02/2014, 16:20

... 5¢-AGATCTTATCACTCCCTTACTAAGTCGATG-3¢ for the b subunit and 5¢-CATATGAGCGAGAAAACCA TGCGCGTGCAG-3¢ and 5¢-AGATCTTAGCTTCCTTT ACGCAGCTTATGC-3¢ for the c subunit. The segments were digested with NdeIandBglII ... Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Tsushima-naka, Okayama 700–8530, Japan. Fax: + 81 86 2518264, E-mail: toraya@biotech.okayama-...

Ngày tải lên: 21/02/2014, 03:20

... implementation of SOMO (SOlution MOdeller) in the UltraScan analytical ultracentrifugation data analy- sis suite: enhanced capabilities allow the reliable hydro- dynamic modeling of virtually any ... Italy Introduction Integrins are heterodimeric transmembrane (TM) cellu- lar receptors involved in mechanical anchoring and two-way signaling [1]. Each a and b subunit has a modular str...

Ngày tải lên: 18/02/2014, 04:20

... alpha- sarcin: a study of relationships. Meth Enzymol 341, 335–351. 3 Lacadena J, A ´ lvarez-Garcı ´ a E, Carreras-Sangra N, Herrero-Gala ´ n E, Alegre-Cebollada J, Garcı ´ a- Ortega L, On ˜ aderra ... 2385 involvement of a catalytic pair constituted by an acid and a base on each side of the hydrolyzed bond [16]. E96 and H137 in a- sarcin and E58 and H92 in RNase T1 act as t...

Ngày tải lên: 18/02/2014, 08:20

... distance data by dynamical simulated annealing from a random array of atoms. Circumventing problems associated with folding. FEBS Lett. 239, 129–136. 31. Laskowski, R .A. , Rullmann, J .A. , MacArthur, ... the inactivation of the Na + channel in a fashion similar to that of scorpion a- toxins [11], other experiments have shown that, at low doses, it has an analgesic activity in...

Ngày tải lên: 20/02/2014, 11:20

... duplex at molar ratios of 1 : 1.2 and of 1 : 2.4. Spectra analysis NMR data were analysed and processed with the computer programs XWINNMR , AURELIA [22], and AUREMOL [23] (Bruker, Karlsruhe, Germany). ... final part of the assignment of the NOESY spectra, the number of identified NOEs was increased by comparison of back-calculated spectra with the experimental data [24,25]. B...

Ngày tải lên: 21/02/2014, 00:20

... acting at the terminal stages of haemoglobin degradation are also considered as potential antimalar- ial targets [22,23]. Other proteases related to the matu- ration of parasites and the invasive ... Slater AFG, Beavis R, Chait B, Cerami A & Henderson GB (1991) Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum :a catabolic pathway initiated by a specific p...

Ngày tải lên: 14/02/2014, 14:20