Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx

... Different mechanisms for cellular internalization of the HIV-1 Tat- derived cell penetrating peptide and recombinant proteins fused to Tat Michelle Silhol 1 , Mudit ... not alter the uptake of the Tat CPP. These biochemical evidences con®rmed a pathway for the e ntry of the Tat peptide unrelated to the HS proteoglycan receptors. In...

Ngày tải lên: 21/02/2014, 03:20

... based on the notion of “information nuggets” to assess an- swers to complex questions. As it has become the de facto standard for evaluating such systems, the research community stands to benefit ... engage to marry? 147.2 FACTOID Who did the Prince marry? 147.3 FACTOID Where did they honeymoon? 147.4 FACTOID Where was Edward in line for the throne at the time of t...

Ngày tải lên: 20/02/2014, 12:20

... pro- trudes towards the exterior of the tetramer near loop 275–288 of the opposite monomer. Therefore, the binding and adaptation of this portion of SsCU-NH to the active site of the protease ... ribose and Ca 2+ into the binding site of SsCU-NH was performed using, as a starting reference, the position of the sugar and of the metal in the crystal...

Ngày tải lên: 18/02/2014, 17:20

... the origin of the kingdom Plantae among the phyla of the ancestral kingdom Protozo a [45]. Hence, it is reasonable to suppose a common origin of extant APXs in the ancient line of protists. The ... atalytic function of the C-terminal domain is not apparent [12], and thus the role of the corresponding part of the gene is also unknown. These g ene f usions...

Ngày tải lên: 19/02/2014, 16:20

... produced by the automaton depends on two values: the thresh- old α of the MDI algorithm and the amount of label sequences used for learning. The closer α is to 0, the more general the inferred automaton ... (i) clustered together (and annotated as referring to the same event); (ii) not clustered together (but annotated as referring to the same event); (iii) in...

Ngày tải lên: 20/02/2014, 12:20

... exploitation of host cell signaling pathways by the pathogen. Upon infection, the phosphatases and kinases of several pathogenic bacteria modify host proteins and help in the establishment of the ... Rv2349c Intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity ⁄ phospholipase c 3 plcc [80] 24 plcD Rv1755c Intracellular surviv...

Ngày tải lên: 16/02/2014, 15:20

... changes of the active center, and neither cofactor orientation nor edge -to- edge distance are different in the presence or absence of phosphate [46,47]. The same observation holds true for the packing ... Mg 2+ and FAD as cofactors [9,10]. After binding and decarboxylation of pyruvate, the reduc- ing equivalents are transferred to the neighboring FAD cofactor....

Ngày tải lên: 18/02/2014, 08:20

... affect the type of inhibition and the K i value of the oligopeptides Tat( 1–9) and Trp2 -Tat( 1–9). On the other hand, corres- ponding to the fourfold difference of the K m values of the hydrolysis of ... Val4 of the peptide and the backbone amide hydrogen of Ala743 of the enzyme, between the side chain carbonyl group of Asn7 of Tat( 1–9)...

Ngày tải lên: 20/02/2014, 11:20

... and accuracy, the lectin microarray system is the best tool for a cell profiler’, and it is expected to be applicable for selection of cancer-specific lectins and for quality control of stem cells ... of genes involved in glycosylation and glycan synthesis and the development of bioinformatic tools for their study have been made publicly available as the Jap...

Ngày tải lên: 16/02/2014, 08:20

... leads to the disintegra- tion of the nuclear and cellular membrane [55], leading to cell death and the formation of ETs. Besides augmenting the local concentration of antimicrobial peptides and ... injury, and to enhance phagocytosis and the maturation of dendritic cells. All of these effects will augment the uptake, processing and presentation of...

Ngày tải lên: 18/02/2014, 06:20