Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx
Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx
... BIGH3 (TGFBI) Arg124 mutations in uence the amyloid conversion of related peptides in vitro Implications in the BIGH3- linked corneal dystrophies Clair-Florent Schmitt-Bernard 1,2 , Alain Chavanieu 3 , ... these disabling diseases. Keywords: amyloidosis; keratoepithelin; lattice corneal dys- trophy; granular corneal dystrophy; synthetic peptide. Her...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo Y học: Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA pdf
... methylation of hemimethylated DNA in vitro [17,18]. However, Dnmt1 also shows capabilities for de novo methylation of DNA [15]. Interestingly, the de novo activity of Dnmt1 is stimulated by binding ... methyl groups are always introduced, one slowly by Dnmt3a or by de novo methylation catalyzed by Dnmt1 and the second one very fast. Therefore, this effect can only double the r...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo Y học: A novel, inducible, citral lyase purified from spores of Penicillium digitatum docx
... depend- ence of the conversion was determined by varying the temperature during the incubation from 0.4 to 45 °C. The pH dependence of the conversion was determined by varying the pH form 5.66–10.19 (by ... as the standard. RESULTS Induction of citral lyase Initially, the reproducibility of the results was hindered by variations in the citral lyase activity...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo Y học: Ligand interactions and protein conformational changes of phosphopyridoxyl-labeled Escherichia coli phosphoenol pyruvate carboxykinase determined by fluorescence spectroscopy pdf
... high binding affinity of PEP in the presence of Mn 2+ [28]. The high affinity of PEP in the presence of Mn 2+ suggests a specific interaction between these two ligands in the enzyme active site. In the ... structure of E. coli PEP carb- oxykinase (1OEN) is covalently linked to the carbonyl carbon of the P-pyridoxyl group (PL) through an imino linkage. The gree...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo Y học: The glucose-specific carrier of the Escherichia coli phosphotransferase system Synthesis of selective inhibitors and inactivation studies pptx
... were recently introduced for the preparation of C-6 aldehyde derivatives of Glc [15]. The key step is the use of Collins reagent for the selective oxidation of the primary trimethyl- silyl ether of the ... that dephosphorylation and/or catalytic turnover of EII Glc , rather than binding of Glc, enhanced the reactivity of Cys421. As Cys421 is the only invariant...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf
... chains of pectin. This is in agreement with a previous study in which the synergy of enzymes degrading the pectin side chains was studied [34]. GALA had a positive effect on the activity of the ... with both the pectinolytic genes encoding main chain cleaving enzymes as well as with the arabinanolytic genes [1]. The absence of expression of galA in the presence...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf
... of Mn[G77Q] and the very low thermostability of Fe[A141Q] (Fig. 5). Each of these mutants has two glutamine residues in their active sites; one from the Ônaturally occurringÕ residue, the other engineered ... residues, causing a shift in the position of Y3 4 and a twist in the ring of the metal- binding H81. Thermostability is not a new phenomenon amongst SODs; th...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo Y học: The structures of the lipooligosaccharide and capsule polysaccharide of Campylobacter jejuni genome sequenced strain NCTC 11168 pdf
... characterization of specific enzymes that are involved in the biosynthesis of these structures and may lead to the discovery of potential therapeutic targets. In addition, the correlation of carbohydrate ... conclusively demonstrate the linkage of the capsule polysaccharide to its membrane anchor and are currently trying to determine the nature of the membrane lin...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo Y học: Soluble silk-like organic matrix in the nacreous layer of the bivalve Pinctada maxima A new insight in the biomineralization field pptx
... previously [20]. The serine, threonine and tyrosine contents of the hydrolysates were corrected for destruction during the hydrolysis by extrapolation to zero time hydro- lysis. The amino acid ... revealed the predominance of two amino acids: alanine (39.2%) and glycine (30%). Interestingly, the proportions are very similar to those found in WSM for alanine and glycine. Curi...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo Y học: Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species pptx
... appearance of the ThDP adduct with the substrate moiety during the complex-catalyzed succinyl-CoA hydro- lysis [72] accounts for the inactivation by dihydrolipoamide in the presence of succinyl-CoA ... (b) the thiyl radical of the lipoyl residue should efficiently interact with the E1 catalytic intermediate, as the lipoyl-bearing domain of E2 is designed for this in...
Ngày tải lên: 21/02/2014, 01:21