Tài liệu Báo cáo khoa học: Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain ppt

... 2003 Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain Dagmar Galter1, Andrea Carmine1,2, Silvia Buervenich1,2, Gregg Duester3 and ... signiﬁcant involvement of ADH1 and ADH4 in ethanol oxidation in brain tissue. Regardingretinoid metabolism in the adult brain, enzymes other thanADH4 must be active, because in vivo and in vitro ... activity in human [9], and by immunohisto-chemistry also in rodents [22].Expression of ADH3 in the adult rodent and human brain Overviews of the expression patterns of the three classes of ADHs...

Tài liệu Báo cáo khoa học: Synchronization of Ca2+ oscillations: a capacitative (AC) electrical coupling model in neuroepithelium pptx

... cadherin interacts withF-actin via b-catenin and a-catenin; b-catenin bindsto cadherin and a-catenin, which in turn interacts withF-actin (Fig. 3A) [24]. Thus b-catenin plays a pivotalrole in the ... Ca2+store or the ONM [4,7]. The store BK channels are activated by apositive voltage change on the luminal side and by anincrease in the luminal [Ca2+] [4,7]. Because the clos-ing of the store ... FEBSadherent cells, the synchronous increase in [Ca2+]between the cells could lead to a signiﬁcant change in the homophilic binding of cadherins. The coactivation of Pyk2 ⁄ Src kinase between the cells...

Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx

... ﬁrst identiﬁed in the epithelial lining of the gut and skin, and subse-quent studies have shown it to play a role in the regu-lation of cellular growth and differentiation in thesetissues [1]. ... adhesion to the endothelial surface and prolongation of clotting time following the induc-tion of KLF4 under in ammatory states, and implicat-ing KLF4 as a regulator of endothelial activation in response ... ele-ments in the promoters. By using matinspector and TESS, we found the promoter of human scavengerreceptor class B type I (hSR-BI) containing multipleputative KLF4 binding sites. Among them, the...

Tài liệu Báo cáo khoa học: Dimers of light-harvesting complex 2 from Rhodobacter sphaeroides characterized in reconstituted 2D crystals with atomic force microscopy docx

... large part of their internalvolume for functionalized invaginations of the intracyto-plasmic membrane containing the photosyntheticmachinery. The most abundant protein complexes in the intracytoplasmic ... energy-transducing network. Protein packing may play a determining role in the formation of functional photosynthetic domains and membrane curvature.To further investigate in detail the packing effects of ... shape of the protein complexes, showed the importance of protein-packing effects on the formation of like-proteindomains, membrane curvature, and the creation of dif-fusive pathways within crowded...

Tài liệu Báo cáo khoa học: Association of feather colour with constitutively active melanocortin 1 receptors in chicken docx

... between the mainly black feathercolour of chickens possessing E and ER and the presence of constitutively active MC1 receptor is in line with the previous observation of the E92K mutation in otherspecies. ... lLofthesupernatant after addition of [3H]cAMP and bovineadrenal binding protein and incubation for 2 h at 4 °C.Standards containing nonlabeled cAMP were assayed in the same manner. The incubates ... stimulatetyrosinase, the rate-limiting enzyme in the synthesis of bothclasses of melanin pigments, eumelanin and phaeomelanin.A low level of tyrosinase expression leads to increasedphaeomelanin synthesis,...

Tài liệu Báo cáo khoa học: Cell surface nucleolin on developing muscle is a potential ligand for the axonal receptor protein tyrosine phosphatase-r ppt

... nonspe-ciﬁc, disruptive effect on the binding of antibodies toantigens such as laminin and myosin (data not shown).Both HB-19 and lactoferrin bind to the C-terminalRGG domain of nucleolin. Therefore, ... outusing the protein lactoferrin. Lactoferrin, an iron-binding protein of the transferrin family, is present in external secretions and the secondary granules of ACEFGDBFig. 5. HB-19 and ... PTPr-binding protein. Nucleolin expressioncorrelates with the location of PTPr-binding sites ondeveloping muscle, and nucleolin-binding proteins and peptides can perturb this PTPr binding. These...

Tài liệu Báo cáo khoa học: Motion of the Ca2+ -pump captured ppt

... single line scan data obtained with buffer conditions. (A) Representative single line scan graphs obtained at increasing ATPconcentration in the range 0–100 lM and in the presence of 10 nM and ... (long-distance move-ment of the N-domain and rotational motion of the A-domain) of SERCA during the ATP-mediated iontransport reaction [14,16–19]. The single line scanning method [8,15], in which anAFM ... ATPhydrolysis of SERCA linearly increased with ATPconcentrations of  1 lm [26]. The lifetime of the elevated conformation (i.e. peakwidth) in the presence of both ATP and Ca2+wasmeasured in the single...

Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

... mediator of lethal sepsis, triggering the production of proinﬂammatory cytokines and liverinjury [13].Therefore, the present study aimed to elucidate the role of KCs in the regulation of CYP isoform ... lead-ing to hepatotoxicity in liver injury, including endotox-emia and ischemia ⁄ reperfusion injury [14]. In ourstudies, we employed GdCl3to inactivate KCs basedon the ﬁndings of other investigators ... [22]. ROS indirectly reduced the activity of selected isoforms of CYP by inducing phosphorylation of the isoforms [23]. Activated KCs cause oxidativestress on the surrounding tissue, releasing largeamounts...

Tài liệu Báo cáo khoa học: Mechanisms of amyloid ﬁbril formation – focus on domain-swapping doc

... ﬁbril building blocks only after partial unfold-ing of the a-helix from the body of the b-sheet(Fig. 2C).Possible role of domain-swapping in the ‘off-pathwayfolding’ (OFF) model The OFF model ... templating and nucleation; (b)linear, colloid-like assembly of spherical oligomers; and (c) domain-swap-ping. In this review, we stress the role of domain-swapping and discuss the role of proline ... taking into consideration the known data, including intrinsic and external factors[83–85]. The universe of proteins capable of formingamyloid-like ﬁbrils has been named the ‘amylome’ [86].The...

Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx

... 1B shows the patternseen after the development of the blot. With increase in time of incubation, the intensity of the band for the monomeric protein decreased, whereas the bands for the higher ... line), in the presence of 100 lM neurotoxin (•, dotted line), in the presence of 200 lM neurotoxin ( , dottedline) and in the presence of neurotoxin and 50 lM dopamine (h, dashed line).Modulation ... solu-tion of ThT and the ﬂuorescence intensity of the solu-tion was measured at 482 nm. Figure 4A shows the kinetics of aggregation of a-synuclein in the presence of 100 lm MPTP and the effect of 50...

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