Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx

... not play a determinative role in conferring the structure of AII. X-ray structure of AII bound to the mAb Fab131: comparison with the NMR solution structure The phenomenon of conformational stabilization ... X-ray structure of AII complexed to the Fab131 mAb. In Fig. 7A, a sequence alignment is represented of the backbone of the...

Ngày tải lên: 20/02/2014, 23:20

... implications of the observed VpUcyt structure One of the most studied activities of VpU is the induc- tion of CD4 degradation in the endoplasmatic reticu- lum of infected CD4 + cells. Only the cytoplasmic domain ... preliminary protein structures [79]. radar runs in an iterative manner. The input of the first cycle consisted of the 3D NOESY data, the amino...

Ngày tải lên: 18/02/2014, 06:20

... invasion. The concerted process of opening of the initial double strand and the annealing of the new duplex finally results in either the replacement of the original strand or the expulsion of the invading strand, ... entropy increase of the system drives binding of the peptide to the RNA (and thus, indirectly, the acceleration of annealing). However...

Ngày tải lên: 14/02/2014, 19:20

... Asp141 of Met8P. The idea of NirF being a dehydrogenase is appealing because of the presence of a putative nucleotide-bind- ing motif in the N-terminal of the protein sequence and also because there ... activity of NirF Interestingly, like NirN, NirF shares sequence similar- ity with the C-terminal d 1 heme-containing domain of cytochrome cd 1 . Strikingly, the a...

Ngày tải lên: 15/02/2014, 01:20

... stimulates intrinsic tyrosine kinase activity of the receptors and triggers autophosphorylation of specific tyrosine residues within the cytoplasmic regula- tory domain. These phosphorylated tyrosines ... signal transducers then bind to these adaptors to initiate mul- tiple signalling pathways, including mitogen-activated protein kinase, phosphatidylinositol 3-kinase ⁄ AKT and the...

Ngày tải lên: 16/02/2014, 09:20

... result in repositioning of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor and thereby stabilize the interaction with EGF-TKIs, leading to an increase ... mutations result in reposition- ing of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor and thereby stabili...

Ngày tải lên: 16/02/2014, 09:20

... splicing of the E2-responsive gene, oxytocin [90]. NRs also interact with the SR (serine- and arginine-rich proteins) family of splicing factors. CAPER, a SR-like protein, interacts with ERa and the ... promoters of cathepsin D and pS2 along with ERa in an E2-dependent manner. In addition to the direct interaction of MLL2 with ERa, MLLs may interact with ERs vi...

Ngày tải lên: 16/02/2014, 14:20

... proteins. Thus, the MEN1 ⁄ LEDGF-interacting domain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHD domains, the FYRN domain, the transactivating domain, the ... elongation of HIV-1 is regu- lated by the TAT ⁄ TAR ⁄ P-TEFb system [38]. Therefore, CDK9 inhibitors may be a promising tool with which to gain insight into the molecular...

Ngày tải lên: 16/02/2014, 14:20

... assigned in the central part of these proteins (Fig. 6). These proteins are the activating enzyme involved in quinohemopro- tein amine dehydrogenase biosynthesis, which is involved in the cross-linking ... [28,29], and the increase in spin quantification is likely to be a conse- quence of the increase in redox potential that results from AdoMet binding [30]. In cont...

Ngày tải lên: 16/02/2014, 14:20

... interface [8,9]. BTB ⁄ POZ proteins are often transcriptional regulators containing a C 2 H 2 domain for DNA binding, but can also be found in combination with various other protein–protein inter- action ... proteins use their BTB ⁄ POZ domain to interact with the cullins CUL3A and CUL3B [3,4,16], we inves- tigated what kind of protein–protein interactions were facilitated by thei...

Ngày tải lên: 18/02/2014, 06:20