Tài liệu Báo cáo khoa học: A single amino acid substitution of Leu130Ile in snake DNases I contributes to the acquisition of thermal stability A clue to the molecular evolutionary mechanism from cold-blooded to warm-blooded vertebrates docx

... A single amino acid substitution of Leu130Ile in snake DNases I contributes to the acquisition of thermal stability A clue to the molecular evolutionary mechanism from cold-blooded to warm-blooded ... DNases I. AmphibianDNasesIhaveaSer205insertioninaCa2+-binding site of mammalian and avian enzymes that reduces their thermal stabilities [Takeshita, H., Yasuda, T., Iida, R., Nakajima, T.,Mori, ... byinsertion of a Ser residue into the Ca2+-binding site,resulting in thermal instability compared with DNases I from mammals and birds [14]. Fish DNase I alsoexhibited similar low thermal stability...

Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf

... comprising animportant sequence for the interaction with the PDZproteins: Mint-3, AMPA binding protein and gluta-mate receptor interacting protein (GRIP). It wouldtherefore be interesting to ... Uekita T, Gotoh I, Kinoshita T, Itoh Y, Sato H,Shiomi T, Okada Y & Seiki M (2004) Membrane-type 1matrix metalloproteinase cytoplasmic tail-bindingprotein-1 is a new member of the Cupin ... GRASP55using a mammalian two-hybrid (M2H) system. Usingthis approach, we have identiﬁed the GRASP55 bind-ing site in the ICD of MT1-MMP, as well as the GRASP55 domains involved in the interaction withMT1-MMP...

Tài liệu Báo cáo khoa học: Staphylococcal enterotoxin C1-induced pyrogenic cytokine production in human peripheral blood mononuclear cells is mediated by NADPH oxidase and nuclear factor-kappa B doc

... (SigmaChemical Co.) in HBSS into the stainless cell of the system. The area under the curve was calculated to obtain totalchemiluminescence.Statistical analysis The animals were maintained at an ... rabbits was in parallel with the levels of interleukin-1b and interleukin-6 in the supernatants. The release of interleukin-1b and interleukin-6, nuclear translocation of NF-jB and itsDNA binding ... monoclonal IgG. b-actin was similarly assessed to serve as a loading control. The intensity of the individual protein signal was normalized to that of b-actin, with Ctl levels arbitrarily set to 1....

Tài liệu Báo cáo khoa học: Various secretory phospholipase A2 enzymes are expressed in rheumatoid arthritis and augment prostaglandin production in cultured synovial cells docx

... with only moderate staining in the interstitium (purple arrows). (C–E) Staining of sPLA2-V in three active RA tissues. In all cases, intense staining of the granulation tissue in the sublining ... expressed in synovial lining cells in the section from a patient with active RA (Fig. 2B,C). Staining of the synovial sublining area was also signiﬁcant, andthere was scattered expression in mononuclear ... (Fig. 4Bd), was negligible. Thus, sPLA2-IIE is induced rather speciﬁcally in VSMC in synovialtissues with active RA. In inactive RA sections, sPLA2-IIF showed sporadicand weak staining in...

Tài liệu Báo cáo khoa học: "Phrase-Based Translation Model for Question Retrieval in Community Question Answer Archives" ppt

... type of parallel corpus, which is used forestimating the translation probabilities. Unlike the bilingual machine translation, the questions and an-swers in a Q& ;A archive are written in the ... traditional adhoc information re-trieval. To make full use of the large scale archives of question-answer pairs, it is critical to have func-tionality helping users to retrieve historical answers(Duan ... This model learns the probability of translating one sequence of words(e.g., phrase) into another sequence of words, e.g.,translating a phrase in a historical question into an-other phrase in...

Tài liệu Báo cáo khoa học: "SenseLearner: Word Sense Disambiguation for All Words in Unrestricted Text" doc

... word sense disambiguation consists of assigning the most appropriate meaning to a polyse-mous word within a given context. Applications suchas machine translation, knowledge acquisition, com-mon ... words in a text. The algorithm can be thought of as a minimally supervisedword sense disambiguation algorithm, in that it uses a relatively small data set for training purposes, andgeneralizes the ... learned from the training data to disambiguate the words in the test data set. As a result, the algorithm does not need a separate classi-ﬁer for each word to be disambiguated, but instead itlearns...

Tài liệu Báo cáo khoa học: "Empirically Estimating Order Constraints for Content Planning in Generation" pptx

... amongthem. This model, being probabilistic in nature,means a great deal of variation, but our gener-ated plans should have variability in the right po-sitions. This is similar to ﬁndings of ﬂoating ... Association for Computa-tional Linguistics (ACL’95).Irene Langkilde and Kevin Knight. 1998. The practi-cal value of n-grams in generation. In Proceedings of the Ninth International Natural Language ... text. In this paper, we present a method for learn-ing the basic patterns contained within a plan and the ordering among them. As training data, weuse semantically tagged transcripts of domain...

Tài liệu Báo cáo khoa học: "Generating statistical language models from interpretation grammars in dialogue systems" potx

... generating Nu-ance recognition grammars from the interpretationgrammar and the possibility of generating corpora from the grammars. The interpretation grammarfor the domain, written in GF, translates ... im-provement in recognition performance. We areconsidering basing our re-ranking on the informa-tion held in the dialogue information state, knowl-edge of what is going on in the graphical interfaceand ... both in dialogue systemsand dictation applications is to ﬁrst write an in- terpretation grammar and from that generate anartiﬁcial corpus which is used as training corpusfor the SLM (Raux et al,...

Tài liệu Báo cáo khoa học: "An annotation scheme for discourse-level argumentation in research articles" doc

... considerable value to the information contained in the training material. Study III tries to answer the question whether the considerable training effort used in Studies I and II can be reduced. ... summarization task we are particularly interested in having them annotated consistently in our training material. The anno- tators were less good at determining BASIS and CONTRAST. This might have to ... If it were the case that coders with hardly any task-specific training can produce similar results to highly trained coders, the training material could be acquired in a more efficient way....

Tài liệu Báo cáo khoa học: "Joint Word Segmentation and POS Tagging using a Single Perceptron" docx

... betweensegmentation and POS information in reducing the combined search space. Instead, a novel multiplebeam search algorithm is used to do decoding efﬁ-ciently. Candidate ranking is based on a discrimina-tive ... “bNN” indicates a character at the beginning of a noun. Using this method, POSfeatures are allowed to interact with segmentation.888Since tagging is restricted to characters, the searchspace is ... more than N times in the training data, the de-coder can only assign a tag the word has been seenwith in the training data. This method led to im-provement in the decoding speed as well as the...

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