... that a truncated mutant containing five amino acids of theextracellular domain and devoid of any tag was notfunctional [27], while a mutant containing four amino acids of the ectodomain and including ... strongly argue for a different conformation between the receptor activated by cleavage and shedding on the one hand, and the receptoractivated by the ligand on the other hand. Cleavage andshedding of ... Chazenbalk, G.D., Tanaka, K., Nagayama, Y., Kakinuma, A. ,Jaume, J.C., McLachlan, S.M. & Rapoport, B. (1997) Evidence that the thyrotropin receptor ectodomain contains not one, buttwo, cleavage...