Tài liệu Báo cáo khoa học: "Measures of Distributional Similarity" ppt

... the intersection Vqr of the supports of q and r. This is of interest from a computa- tional point of view because Vqr tends to be a relatively small subset of V, the set of all verbs. Furthermore, ... purpose of improving probability estima- tion for unseen cooccurrences. Our contribu- tions are three-fold: an empirical comparison of a broad range of measures; a classification of similarity ... pirical comparison of a broad range of similarity metrics using an evaluation methodology that factors out inessential degrees of freedom; a pro- posal, building on this comparison, of a charac-...

Tài liệu Báo cáo khoa học: Motion of the Ca2+ -pump captured ppt

... period of observation in the presence of both ATP andCa2+were excluded from the following analyses.Visual characteristics of the Albers–Post schemeThe number of peaks (i.e. the number of up–downconformational ... Histograms of the height differences between the top of SERCA and the surface of the membrane. Statistical section analy-ses of SERCA were performed with the data obtained in the pres-ence of (A) ... ATP-unbound and Ca2+-boundE1Ca2+form. In the histogram (Fig. 2A) of the dis-tribution of the height of the projection of the embed-ded molecule above the ﬂat membrane surface, theaverage...

Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

... the inhibition of CYP activity observed in theabsence of changes in protein expression in rabbit he-patocytes [22]. ROS indirectly reduced the activity of selected isoforms of CYP by inducing ... hepatic mRNA level of CD163 compared to that of sham group. Twenty-fourhours after cecal ligation and puncture (CLP), thehepatic mRNA level of CD163 was similar with that of the sham group, ... phosphorylation of the isoforms [23]. Activated KCs cause oxidativestress on the surrounding tissue, releasing largeamounts of ROS during sepsis [24]. Interestingly, phos-phorylation of CYP1A1 ⁄...

Tài liệu Báo cáo khoa học: Mechanisms of amyloid ﬁbril formation – focus on domain-swapping doc

... only after partial unfold-ing of the a-helix from the body of the b-sheet(Fig. 2C).Possible role of domain-swapping in the ‘off-pathwayfolding’ (OFF) modelThe OFF model for amyloid formation ... ourunderstanding of the importance of different parts of the molecule and their ﬂexibility in the process of amy-loid ﬁbril formation often results more from a struc-tural analysis of the amyloid ... parts of the protein molecule (e.g. either pro-tonation of a number of side chains, binding of metalsto an unfolded state or mutations at speciﬁc sites) arekey to amyloid formation. One of the...

Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx

... solu-tion of ThT and the ﬂuorescence intensity of the solu-tion was measured at 482 nm. Figure 4A shows thekinetics of aggregation of a-synuclein in the presence of 100 lm MPTP and the effect of 50 ... Admin-istration of MPTP has also been shown to formaggregates of a-synuclein in nigral neurons of baboons(Papio anubis) [11]. Depletion of a-synuclein was maxi-mum in the middle third region of substantia ... theformation of aggregates of the protein on exposure todopamine [16]. In vitro experiments probably provide abetter understanding of the role of various interactingcomponents. The formation of dopamine–quinoneadducts...

Tài liệu Báo cáo khoa học: Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels pptx

... pore (PTP) [1,2], is of asufﬁcient size (cut-off of $ 1.5 kDa) to allow the pas-sage of solutes and water, which may also result inrupture of the outer membrane. The identity of theproteins comprising ... deamination [30]. The lack of oxida-tion of 1 mm glutamate in the presence of 5 mmsuccinate can be demonstrated by a complete lack of effect of rotenone on recordings of membrane poten-tial from ... Effect of CYPD ablation or its inhibition by cyclosporin Aon the rates of respiration of mouse liver mitochondria. ACI, accep-tor control index, the rate of respiration in the presence of AsO4divided...

Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx

... interaction of both proteinsor by binding of CagAPYto Csk, a negative regulator of Src [6,7]. Because Src is the primary kinase phos-phorylating CagA in the EPIYA-motifs, inhibition of Src by ... the disrup-tion of cell–cell junctions, a loss of cell polarity andthe induction of pro-inﬂammatory and mitogenicresponses (Fig. 3C). The ﬁrst detected interaction part-ner of nonphosphorylated ... represents one of the most successful humanpathogens, inducing severe clinical symptoms only ina small subset of individuals, mirroring a highlybalanced degree of co-evolution of H. pylori andhumans....

Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf

... Galaris11 Laboratory of Biological Chemistry, University of Ioannina Medical School, Greece2 First Division of Internal Medicine and Hepato-gastroenterology Unit, University of Ioannina Medical ... presence of relatively low amounts of oleate protected cells from stearate-induced toxicityand restored the ability of the cells to accumulate triacylglycerols. Our datasuggest that interruption of ... endoplasmic retic-ulum, apparently because of the formation of a pool of oversaturated inter-mediates, represents the key initiating event in the mechanism of saturatedfatty acid-induced lipotoxicity.AbbreviationsACS,...

Tài liệu Báo cáo khoa học: Kinetics of dextran-independent a-(1 ﬁ 3)-glucan synthesis by Streptococcus sobrinus glucosyltransferase I pdf

... presence of increasing DPmay be a common feature of glucansucrase.Additional studies are required to elucidate the dex-tran-dependent synthesis of glucan. As the afﬁnity of the GBd of GTF-I ... Kodama11 Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Japan2 Department of Oral Microbiology, Okayama University Graduate School of Medicine, Dentistry, ... degree of polymerization of 2–6 and methyl a-D-gluco-pyranoside as a glucose analog indicate that the activity increased with anincrease in the degree of polymerization. The production of insoluble...

Tài liệu Báo cáo khoa học: Regulation of DNA fragmentation: the role of caspases and phosphorylation doc

... theinduction of DNA fragmentation, which is one of themost typical characteristics of apoptosis.Regulators of DNA fragmentationOne of the terminal processes of apoptosis is DNAdegradation. During ... translocation of Bax and Bad to mitochon-dria independently of caspase activation [77,87].Phosphorylation of caspasesPhosphorylation of caspases switches the cellular apop-totic signal on and off. ... inregulating the activity of an isoform of PP1, PP1a [3].Similarly, activation of caspase-8 and -3 is regulatedthrough their phosphorylation and dephosphorylation.Phosphorylation of caspase-8 at Tyr397...

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