Tài liệu Báo cáo khoa học: "Lexicalized Stochastic Modeling of Constraint-Based Grammars using Log-Linear Measures and EM Training" ppt

Tài liệu Báo cáo khoa học: Multi-targeted activity of maslinic acid as an antimalarial natural compound pdf

... chemical structures need to be encoded using some sort of mathematical descriptors. In this work,three types of two-dimensional descriptors were used, namelyphrag, fpd and shed, each one of ... shed, each one of them characterizing chem-ical structures with a different degree of fuzziness and thuscomplementing each other in terms of structural congenerici-ty and hopping abilities ... chalcones and phenothiazines have beenassayed as inhibitors of falcipain-2 [20,21]. Inhibition of the metalloproteases falcilysin and neutral amino-peptidases acting at the terminal stages of haemoglobindegradation...

Tài liệu Báo cáo khoa học: C-Terminal extension of a plant cysteine protease modulates proteolytic activity through a partial inhibitory mechanism doc

... digested using the abovementioned proteases (90 lg) atthe optimum pH and temperature of activity of each prote-ase. In brief, digestion by Erv-A, Erv-B, Erv-C were carriedout at pH 8.0 and 37 ... [15]. Sequencing of the cDNA (from mRNA) of Erv-C from the leaf of the plant in our laboratory [16], and comparison of the cDNA-derived amino acid sequence with othermembers of the family reveal ... activity of the enzyme against a smallpeptide.Thermal stabilityTemperatures of maximum proteolytic activity (Tmax)for rproErv-C+CT and rproErv-CDCTare 50 and 45 °C(Table 2 and Fig. 4) and...

Tài liệu Báo cáo khoa học: Seeking the determinants of the elusive functions of Sco proteins pptx

... essential role of the Cu(II) state of Sco inthe maturation of the Cu(A) center of cytochrome oxi-dase: evidence from H135Met and H135SeM variants of the Bacillus subtilis Sco. J Biol Inorg Chem 16, ... BsSco, a member of the Sco family of cytochrome c oxidase assembly pro-teins. Biochemistry44, 2934–2942.34 Andruzzi L, Nakano M, Nilges MJ & Blackburn NJ(2005) Spectroscopic studies of metal ... Characterization of theredox and metal binding activity of BsSco, a proteinimplicated in the assembly of cytochrome c oxidase.Biochemistry 44, 16949–16956.36 Davidson DE & Hill BC (2009) Stability of...

Tài liệu Báo cáo khoa học: Glycomics-based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay docx

... wereselected.MALDI-TOF/TOFIn addition to LC-MS ⁄ MS analysis, we also completedTOF ⁄ TOF analysis of selected peaks to conﬁrm structure using a MDS Sciex 4800 MALDI-TOF ⁄ TOFÔ instru-ment (Applied Biosystems) ... software. TOF ⁄ TOF fragmentation spectrawere recorded using negative-ion linear mode with stan-dardized MS ⁄ MS acquisition and processing methods aftertuning of the instrument. TOF ⁄ TOF ... theability of two well-characterized HAs from prototypic,pandemic inﬂuenza strains, A ⁄ South Carolina ⁄ 1 ⁄ 1918H1N1 (SC18, 1918 pandemic) and A ⁄ Albany ⁄ 6 ⁄ 1958H2N2 (Alb58, 1957 pandemic),...

Tài liệu Báo cáo khoa học: Intrinsic GTPase activity of a bacterial twin-arginine translocation proofreading chaperone induced by domain swapping ppt

... of the twodistinct functions of TorD with the folding of TorA and possible interactions of both proteins with theMGD biosynthetic apparatus [12]. The concentration of GTP in the cytoplasm of ... in assembly and export of N-oxidereductases. Biochem Soc Trans 33, 124–126.29 Zhang B, Zhang Y, Wang Z & Zheng Y (2000) Therole of Mg2+cofactor in the guanine nucleotideexchange and GTP ... prevent premature export of some Tat-targeted proteins until all other assembly processes are complete.TorD is a paradigm Tat proofreading chaperone and co-ordinates the mat-uration and export of...

Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

... ⁄ CHR tandemelement is not occupied by proteins in later cell cyclephases and is not necessary for activation of thepromoters.Conclusions and perspectivesWhat deﬁnes CDE and CHR elements? ... homologs of Caenor-habditis elegans synMuvB proteins and is composed of p130, E2F4 ⁄ 5 and DP1 ⁄ 2 and a module containing theMuvB proteins Lin-37, Lin-52, Lin-54 and chromatin-associated Lin-9 and ... central role of CDE/CHR promoter elements in theregulation of cell cycle-dependent gene transcriptionGerd A. Mu¨ller and Kurt EngelandMolecular Oncology, Department of Obstetrics and Gynecology,...

Tài liệu Báo cáo khoa học: Minor capsid proteins of mouse polyomavirus are inducers of apoptosis when produced individually but are only moderate contributors to cell death during the late phase of viral infection ppt

... levels of apoptotic markersduring the late stages of MPyV infection. However,comparison of the levels of apoptotic markers and cytotoxicity during the replication of wt MPyV, and replication of ... with wtVP2 and VP3 and the fusion variants VP2–EGFP and VP3–EGFP.To further examine the membrane localization of the cytoplasmic fractions of fusion proteins, themutual location of membranes ... fast and efﬁ-ciently and are associated not only with a damagedER, but also with mitochondrial and other intracellu-lar membranes.The observed association of VP2 and VP3 withdamaged membranes...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx

... regulation and mixed lineageleukemia.AcknowledgementsWe thank Imran Hussain, Sahba Kasiri, BishakhaShrestha, Saoni Mandal and other Mandal lab mem-bers for useful discussion and critical ... evidenced by lowlevels of Hoxa1 , higher levels of Hoxa3 and Hoxa5 and the complete absence of Hoxa2, Hoxa4 and Hoxa6 expression [28]. These studies also demon-strated that Hoxa7 and Hoxa9 are required ... that mutation of Taspase 1 resultsin the downregulation of cyclin E, A and B, and upreg-ulation of p16 (an S-phase inhibitor). MLL1 binds tothe promoters of cyclin E1 and E2 and there is amarked...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human pptx

... expression.The signiﬁcance of understanding regulation of H3K4 methylation is exempliﬁed by the occurrence of cancers and other diseases following mutations of H3K4 methyltransferases and demethylases or ... TRX or other HMTs [100]. Bothnucleosome remodeling factor and ATP-utilizing chro-matin assembly and remodeling factor are ATP-depen-dent remodelers and carry ISW1 as an ATPase subunit[100]. ... demethylation of methylated K4 and K9 of histone H3. Such a demethylation process hasimportant roles in the regulation of chromatin struc-ture and hence gene expression.H3K4 methylation and...

Tài liệu Báo cáo khoa học: An autoinhibitory effect of the homothorax domain of Meis2 ppt

... control of two copies of a canonical Meis–Pbx-binding site and a minimal TATA element, and one with two copies of the Hoxb1 auto-regulatory ele-ment (ARE) r3 element [9]. Coexpression of Meis2d and Pbx1 ... effect of the homothorax domain of Meis2Cathy Hyman-Walsh, Glen A. Bjerke and David WottonDepartment of Biochemistry and Molecular Genetics, and Center for Cell Signaling, University of Virginia, ... is a member of the TALEsuperfamily of HD proteins, which are characterizedby the presence of a three amino acid loop insertionbetween helices 1 and 2 of the HD [13–15]. The pres-ence of this...

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