Tài liệu Báo cáo khoa học: "Exploiting Structure for Event Discovery Using the MDI Algorithm" doc

... weinvestigate event discovery using a corpus of newsarticles relating to the recent Iraqi War where the tar-get event is the “Death” event type. Figure 1 showsa sample article depicting such events. The ... text, extract the relevant arguments of the event, and represent the extracted information intoa structured form (Grishman, 1997). The types ofevents to extract are known in advance. For exam-ple, ... Proceedings of the ACL 2007 Student Research Workshop, pages 31–36,Prague, June 2007.c2007 Association for Computational LinguisticsExploiting Structure for Event Discovery Using the MDI AlgorithmMartina...

Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx

... in3.7% (v/v) formaldehyde in NaCl/Pi for 5 min at roomtemperature. For experiments at 4 °C, the protocol was the same except that all incubations were performed at4 °C until the end of the ®xation ... not alter the uptake of the Tat CPP. Thesebiochemical evidences con®rmed a pathway for the e ntry of the Tat peptide unrelated to the HS proteoglycan receptors.Internalization of the Tat CPP ... additionalevidences for separate entry routes for the Tat CPP and the Tat protein.What might be the reasons underlying the observeddifferences in cellular uptake between the Tat CPP and the GST±Tat±GFP...

Tài liệu Báo cáo khoa học: Crystal structure of an ascomycete fungal laccase from Thielavia arenaria – common structural features of asco-laccases ppt

... to another confor-mation to open the T2 channel (Fig. 3B). On the basisof protein structure libraries, the ‘open conformation’would be the second most favoured conformation. On the other hand, ... aretherefore EPR silent, although these coppers causeabsorbance at 330 nm. The loops surrounding the T1copper form the phenolic substrate-binding site of the enzyme, whereas the T2 and the ... long enough toform such a plug, as the last visible amino acid (Asn494)is located on the surface of the molecule and is ratherfar away from the trinuclear site. Therefore, the C-terminal sequence...

Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt

... wererecalculated. The normalized B factors from apo importin-awere then subtracted from those in the importin-a:CLIC4NLS structure, and the difference was again normalized using the equation above. The ﬁnal ... competes for the importin-a binding site,reducing binding afﬁnity for cargo proteins and help-ing to facilitate the release of the cargo within the nucleus [10,11]. The removal of the autoinhibitorydomain ... groups. The one exception to this is the location of the amide group of Lys204 at P3, wherethere is a break in the main-chain density at the 2.8rmap level. The corresponding position in the apo...

Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf

... groups: one with almost the sameactivity in the Mn- and Fe-forms, and the other exhib-iting low activity in the Fe-form and high activity inMn-form. ApeSOD belongs to the latter group [16].This ... perspective because the ter-tiary structure of ApeSOD has not been elucidated.In the present study, for the ﬁrst time, we describe the crystal structure of ApeSOD. In particular, we focuson the coordination ... ligands. The additional water occupied the postulated superoxide bind-ing site. The thermal stability of the enzyme was compared with superoxidedismutase from Thermus thermophilus, a thermophilic...

Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc

... wild-typeand mutant structure are in the same range as the dif-ferences between the two molecules of the asymmetricunit of the wild-type structure. Neither the mutationnor the different crystallization ... protein. The atomic displacement factors of the PhyK structure aresmaller for the a ⁄ b domain than for the a domain.This has also been observed for other HAPs. The heli-ces directly involved in substrate ... with Arg28. Therefore, these two conservedarginine residues are important for arranging the sub-strate in the correct orientation for catalysis, whereasHis25 is responsible for the nucleophilic...

Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx

... important for the activity. Given the 3D structure of the HtA active site,and the interactions between side chains, we proposethat D40, H42, R95 and F126 also form part of it. Asin other ribotoxins, ... 0.98 A˚ for all backbone atoms), and the glo-bal fold is similar to that reported for cytotoxins.However, differences can be found in the conformationof loops, the b-hairpin and the relative ... found for C6–C129 and for C57–C108. The long-range NOEs between residues surrounding the cysteines conﬁrm the cysteine pairing deﬁned here.This pattern agrees with the arrangement present inother...

Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx

... identicalresidues. The topological equivalence of the fourTTSPs forms the basis for the sequence alignmentshown in Fig. 3. The numbering in the alignmentrefers to the chymotrypsin numbering. Despite the high ... below). The southern boundary of the active site cleft of DESC1 is formed by the 145autolysis loop. The backbone of this loop differs mark-edly from the other serine proteinases, making the act-ive ... revealsthat the most similar regions of these proteinases medi-ate interaction of the two b-barrels, formation of the catalytic machinery and structures required for bindingof the main chain of the...

Tài liệu Báo cáo khoa học: Crystal structure of the BcZBP, a zinc-binding protein from Bacillus cereus doc

... 1.0 A˚ for the Ca atoms. Thus, the movement of the a2 helix accounts for 23% of the rmsd value (i.e. for approximately one quarter of the structural difference between the enzymes). Theselocalized ... the quartenary structure of the BcZBP in solution is the hexamer found in the crystalsand that this hexamer probably corresponds to the biologically active form of the protein.In terms of thermal ... gray indicates the C-terminal part. The dimer’s formation is established by the incorporation of the b8-strand of one monomer into a b-sheet of the other monomer. The position of the zinc ion is...

Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt

... important in the inhibitorymechanism, in addition to the primary structure of the peptide.To conﬁrm our hypothesis that the b-turn structures areimportant for the inhibitory activities of the peptides, ... better than cER. The cER peptidemay potentially bind to the CD58 protein as indicated by the docking studies. The lowest energy docked structure wasat the top cavity. On the other hand, cVY peptide ... peptides, the structures of the cyclic peptides were determined by NMR. The results proved that the stable b-turn conformationexists in the cyclic peptides. The b-turn regions in thesepeptides...

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