... that the intracellular calcium levelincreased in OccWT-overexpressing cells, and that2-APB inhibited the effects of OccWT. Therefore, the increase in intracellular calcium may explain the induction ... roles in the induction ofmitochondria-mediated apoptosis and the inhibition of invasion, along with the downregulation of matrix metalloproteinase expression. In addition, byusing the calcium indicator ... protein, as a subunit of Ga, induces the forma-tion of inositol trisphosphate (IP3), which binds to the IP3receptor (IP3R) located on the endoplasmic reticu-lum (ER), thereby releasing...