Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf

... studies in Drosophila Schneider cells confirmed that the constitutive expression of this gene is controlled by Ets-1 and requires the presence both of the Sp1 and Sp3 transcription factors. The presence ... endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 Mingfeng Liu 1...

Ngày tải lên: 20/02/2014, 11:20

... immunoblot analysis with the anti-c-Myc IgG. The intensity of the band of the protease domain was quantified using the protease domain of the protein obtained from E. coli . Enzyme inhibition assay HAI-1–K1 ... tissues producing it. In response to tissue injury, such as hepatic and renal injury, the inactive single-chain HGF is converted to a two-chain form exclusivel...

Ngày tải lên: 15/02/2014, 01:20

... 2007 FEBS tolerate lack of ALK3 in absence of the inhibitor. Although functional proof is missing, the authors found up-regulation of ALK1 and ALK2 in these cells and suggest these receptors to be ... occurs outside of the signal receiving cell, by secretion of blocking ligands such as Noggin, Chordin and Follistatin or GDF3. Another way to modulate ligand ⁄ re...

Ngày tải lên: 19/02/2014, 00:20

... protein band from the patterns obtained a t the beginning (Glg2p 0 ) and from the end of the incubation period (Glg2p 20 ) were excised and digested with trypsin in the gel. T he resulting peptide ... of these two enzymes does not permit the de novo synthesis of a glucan. Both in fungi and in animals glycogen biosynthesis appears to b e initiated by the act...

Ngày tải lên: 19/02/2014, 16:20

... domain; and a C-terminal regulatory domain [2]. The extracellular domain is subdivided further into four domains. The tyrosine kinase domain consists of an N-lobe and a C-lobe, and ATP binds to the ... bind to EGFR and ERBB4 (including betacellulin, heparin-binding EGF and epiregulin); and (c) neuregulin (NRG) (also known as heregulin) that binds to ERBB3 and ERBB4. NR...

Ngày tải lên: 16/02/2014, 09:20

... transactivation domain. The DNA-bind- ing domain is responsible for DNA binding specificity and dimerization, and the ligand-binding domain is responsible for binding of the ligand and associated induced ... distinct subset of cofactors, depending on the target gene, binding affinities and relative abun- dance of these factors in the cells [65]. These coactiva-...

Ngày tải lên: 16/02/2014, 14:20

... concerning mechanisms of gene repression by proteins of the NE and suggest the hypothesis that the epigenetic ‘histone code’, dictating transcriptional repression, is ‘written’ in part, at the NE by ... Lining the nucleoplasmic side of the NE, and in close contact with it, is the nuclear lamina (reviewed in [10,10a]). It is a protein meshwork composed...

Ngày tải lên: 19/02/2014, 02:20

... invasion. The concerted process of opening of the initial double strand and the annealing of the new duplex finally results in either the replacement of the original strand or the expulsion of the invading strand, ... determines the magnitude of peptide–RNA binding, owing to counterion release from the RNA backbone [66]. The resulting entropy increase of...

Ngày tải lên: 14/02/2014, 19:20

... mutations result in reposition- ing of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor and thereby stabilize the interaction with EGF-TKIs. Table 2. ... tyrosine kinase domain of the receptor and thereby stabilize the interaction with EGF-TKIs, leading to an increase of  100-fold in sensitivity to inhibition by...

Ngày tải lên: 16/02/2014, 09:20

... proteins. Thus, the MEN1 ⁄ LEDGF-interacting domain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHD domains, the FYRN domain, the transactivating domain, the ... the presence of Meis1 and Pbx proteins, as well as on the presence of Men1 and Ledgf [19–21]. More recently, it has been demonstrated that overex- pressed Meis1 resu...

Ngày tải lên: 16/02/2014, 14:20