... that the SEA domain functions by orienting the active site cleftof DESC1 toward plasma and ⁄ or extracellular spacesand away from the cell surface and ⁄ or the extracellularmatrix. The SEA ... Moun-tain View, CA, USA). Two fragments were isolated andconfirmed by Southern analysis using the internal cDNAfragment as the probe and by DNA sequence analysis. The cDNA encoding DESC1 was cloned ... Shimomura T, Denda K, Kitamura A, Kawaguchi T,Kito M, Kondo J, Kagaya S, Qin L, Takata H,Miyazawa K et al. (1997) Hepatocyte growth factoractivator inhibitor, a novel Kunitz-type serine proteaseinhibitor....