Tài liệu Báo cáo khoa học: "Toward finer-grained sentiment identification in product reviews through linguistic and ontological analyses" ppt
... Proceedings of the ACL-IJCNLP 2009 Conference Short Papers, pages 169–172, Suntec, Singapore, 4 August 2009. c 2009 ACL and AFNLP Toward finer-grained sentiment identification in product reviews through ... propose categories of finer-grained polari- ty for a more effective aspect-based sentiment summary, and describe linguistic and ontolog- ical clues that may aff...
Ngày tải lên: 20/02/2014, 09:20
... shown that interactions between KCs and endotoxin comprise the initiating event lead- ing to hepatotoxicity in liver injury, including endotox- emia and ischemia ⁄ reperfusion injury [14]. In our studies, ... factor-a and interleukin-6, and increased hepatic mRNA levels of tumor necrosis factor-a and interleukin-6 were decreased by depletion of KCs. Our findings suggest that abla...
Ngày tải lên: 14/02/2014, 18:20
... that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain. The DNA-bind- ing domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... domain involved in protein–protein interactions. FYRC and FYRN domains are involved in heterodimerization between MLL N and MLL C terminal fragments. High-mobility group (HMG) dom...
Ngày tải lên: 16/02/2014, 14:20
Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc
... protein monomer. GO cata- lyzes the dioxygen-dependent oxidative deamination of primary and secondary amines (sarcosine, N-ethylgly- cine, and glycine) and d-amino acids (d-alanine and d- proline), ... ones; and (b) progressive optimization for glyphosate activity is accompanied by improved bind- ing to longer ligands (up to five atoms in the main chain) and retained binding to s...
Ngày tải lên: 14/02/2014, 14:20
Tài liệu Báo cáo khoa học: Transient RNA–protein interactions in RNA folding docx
... of opening of the initial double strand and the annealing of the new duplex finally results in either the replacement of the original strand or the expulsion of the invading strand, according to ... to proteins with RNA-annealing activity. DEAD-box proteins should therefore be considered as major players in RNA folding and in the assembly and functioning of RNP machines, mostly th...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf
... binding and PI staining were performed according to [44]. Following incubation with 1.0 lgÆmL )1 annexin V and 4.0 lgÆmL )1 PI for 20 min, cells were analyzed by flow cytometry. Preparation and ... variety of cell types, including hepatocytes, to long-chain saturated fatty acids (SFAs) led to increased expression of proin- flammatory cytokines, inhibition of insulin signaling, induction o...
Ngày tải lên: 14/02/2014, 22:20
Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx
... coiled-coil domain in the N-termi- nus and a fibrinogen-like domain in the C-terminus. Angiopoietins have a signal sequence in the N-termi- nus for protein secretion, and secreted angiopoietin functions ... University, Japan Introduction A worldwide increase in obesity due to lifestyle changes, such as inactivity and overnutrition, is an increasing medical and social problem i...
Ngày tải lên: 14/02/2014, 22:20
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... betacellulin, heparin-binding EGF and epiregulin); and (c) neuregulin (NRG) (also known as heregulin) that binds to ERBB3 and ERBB4. NRG1 and NRG2 bind to both ERBB3 and ERBB4, whereas NRG3 and NRG4 ... domain; and a C-terminal regulatory domain [2]. The extracellular domain is subdivided further into four domains. The tyrosine kinase domain consists of an N-lobe and a C-lobe,...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... The binding of ligand to EGFR induces receptor dimerization and consequent confor- mational changes that result in activation of the intrin- sic tyrosine kinase, receptor autophosphorylation and a ... compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity and EGFR signaling pathways (Fig. 1). Early clinical stud...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Hepatic stimulator substance mitigates hepatic cell injury through suppression of the mitochondrial permeability transition pdf
... uncoupling in hepatocytes leads to PTP opening and cell swelling, an event that is probably reduced in extent by CsA. CsA specifically inhibits PTP opening by binding to cyclophilin D in the matrix and ... detected using Hoechst 33342 staining, vector-transfected cells and cells expressing mutant HSS underwent typical apopto- tic changes [39], including shrinkage, membrane bleb- bi...
Ngày tải lên: 16/02/2014, 09:20