Tài liệu Báo cáo khoa học: Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster doc

... However, the introduction of foreign genes, such as nucleoside kinases, into human cells may affect the metabolism of the target cells in more ways than just the therapeutic purpose of the introduced ... in RNA or protein synthesis between the Dm-dNK expressing cells and their corresponding par- ental cell lines, the incorporation of dCyd was increased in...

Ngày tải lên: 20/02/2014, 01:20

... FXa cofactor activity of the reaction intermediate, FVa int . This facilitated the determination of loss of FVa cofactor activity during the initial stage of inactivation and minimized the in uence ... [40]) to optimize further the positioning of the molecules. Results APC-catalyzed inactivation of FVa in the presence of heparin Heparin strongly in uenced the...

Ngày tải lên: 19/02/2014, 13:20

... localizes in the cytoplasm of human epithelial cells of the gastrointestinal tract and liver, two central organs in the regulation of iron metabolism [20,21]. After their synthesis in the endo- plasmic ... decrease in the percentage of cells in the S and G2 ⁄ M phases of the cell cycle (Fig. 3B). In a total of seven separate determinations, a statisti...

Ngày tải lên: 19/02/2014, 16:20

... RPE65c in the inner retina, including Mu ¨ ller cells, but not in the RPE. Furthermore, double-immuno- staining of dissociated retinal cells using antibodies for RPE65c and gluta- mine synthetase (a ... containing atRE in the presence of 1m M bipyridine (B) and liposomes containing atRE, in the presence of 1 m M bipyridine and 6 mM FeSO 4 (C). The generated retinoid...

Ngày tải lên: 14/02/2014, 14:20

... phosphofructokinase; PFL, pyruvate formate- lyase; Pi, inorganic phosphate; PI3K, phosphatidylinositol 3 -kinase; PIP, phosphatidylinositol 4,5-bisphosphate; PKA, protein kinase A; PKC, protein kinase ... and polyamines NG, aorta endothelial cells Low affinity transporter and arginase share the control of the fluxes through the pathways involving arginine as a precurser of nitri...

Ngày tải lên: 14/02/2014, 14:20

... constitutes the second largest family of cyto- plasmic tyrosine kinases. In 1993, loss -of- function mutations in the BTK gene were reported as the cause of X-linked agammaglobulinemia. Of all the existing ... virus infec- tion. Both kinases represent interesting targets for inhibition: in the case of BTK, as an immunosuppressant, whereas there is evidence that the i...

Ngày tải lên: 14/02/2014, 18:20

... and of the kanamycin insertion mutant nirF strain (SBN03) in the upper right panel. Growth of SBN11 (DnirF) is shown in the bottom left panel and of SBN13 (DnirF) containing pEG276-nirF in the ... activity of NirF Interestingly, like NirN, NirF shares sequence similar- ity with the C-terminal d 1 heme-containing domain of cytochrome cd 1 . Strikingly, the axial lig...

Ngày tải lên: 15/02/2014, 01:20

... attack of the L-hOrn 3 a-amino group onto l-haOrn 4 . Taking into account that the synthetases involved in the bio- synthesis of the DKP-inheriting toxins thaxtomin and fumitremorgin also contain ... pathogens, the interest in the structural and functional characterization of these compounds is growing and may result in the synthesis of specific inhibitors based on...

Ngày tải lên: 16/02/2014, 09:20

... describe here the phenotype of mutant mouse strain 0283. This strain exhibited a phenotype indicative of resistance to diet-induced and genetic obesity. The mutation of the 0283 strain is in the RMI1 ... suggest that the regulation of energy homeostasis was altered in the RMI1+ ⁄ ) mice. The RMI1+ ⁄ ) also gained less intra-abdominal fat (gonadal fat volumes measur...

Ngày tải lên: 16/02/2014, 09:20

... dfla tren tinh tfldng trd, tinh anh em, tinh yeu. 62 Nghien ciiu Kinh tSsd370 - Thang 3/2009 Ban chd't cua cuoc khung khoang cdng bIng, tfl do va binh ding. CNXH the ky XXI ... cac the che tao nen sfl phu thudc tinh thin va vat cha't. Sfl thd'ng tri cua Washington dang KH. Phai tao cac the che thd'ng nha't mdi ciia Chau My Latinh ve chi...

Ngày tải lên: 17/02/2014, 05:20