Tài liệu Báo cáo khoa học: Consequences of COP9 signalosome and 26S proteasome interaction doc

... super-complexes composed of the CSN, the 26S proteasome and of Ub ligases in the regula- tion of protein stability is discussed. Abbreviations CSN, COP9 signalosome; PCI, proteasome -COP9 signalosome- initiation ... the polypeptides of the 26S proteasome lid complex and just like the lid, the CSN consists of six subunits with PCI (proteasome, COP9 signalosome,...

Ngày tải lên: 20/02/2014, 01:20

... of InsP 6 to PhyAsr (Table 1). Given the absence of structural changes as a function of ionic strength and ligand binding, the effect of ionic strength on catalytic activity is probably not of ... move- ment of the P-loop in PhyAsr is due to oxidation of the catalytic cysteine, we oxidized crystals of PhyAsr Table 1. Effect of ionic strength on the hydrolysis of InsP 6 b...

Ngày tải lên: 18/02/2014, 18:20

... Sedla ´ c ˇ ek 3 and Jindr ˇ ich Has ˇ ek 1 1 Institute of Macromolecular Chemistry, 2 Institute of Organic Chemistry and Biochemistry and 3 Institute of Molecular Genetics, Academy of Sciences of the ... alternative positions of phenylalanine rings a re formed in concert with the alternative positions of S d and C c of Met46 and Met146 (from neighbouring protease di...

Ngày tải lên: 19/02/2014, 16:20

... action of EPA and DHA (Eur. J. Biochem. 271) 4465 Modulation of cyclin D1 synthesis and hyperphosphorylation of Rb by n-3 and n-6 PUFAs Induction of cyclin D1 is one of the e arliest effects of mitogenic ... contribute to the modu- lation of egr-1 gene expression (Fig. 4B). Effects of n-3 and n-6 PUFAs on the synthesis of caveolin-1 and caveolin-3 and on the loca...

Ngày tải lên: 19/02/2014, 16:20

... to learn thou- sands of Chinese characters. The official agents in Taiwan and China, respectively, chose 5401 and 3755 characters as important basic characters in national standards. Consequently, ... e.g., “賣” and “讀” are pronounced as /mai4/ and /du2/, respectively. In contrast, the pro- nunciations of “匋”, “淘”, “陶”, and “啕 ” are /tao2/. Pronunciations of specifi...

Ngày tải lên: 19/02/2014, 19:20

... Institute of Science and Technology, Ishikawa, Japan; 2 Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan; 3 Department of Synthetic Chemistry and ... T m of lysozyme was 77.3 °C in the absence of additives. The addition of 100 m M polyamines and Arg slightly increased the T m of lysozyme by  1 °Cand0.5°C, respectively...

Ngày tải lên: 20/02/2014, 02:21

... Program of the Office of the Director of NIH and by AIDS FIRCA Grant TW01001. The contents of this publication do not necessarily reflect the views or policies of the Department of Health and Human ... Louis 3 , Terry D. Copeland 4 , Ivan Y. Torshin 5 , Robert W. Harrison 5 and Jo ´ zsef To¨ zse ´ r 1 1 Department of Biochemistry and Molecular Biology, Faculty of Medicine...

Ngày tải lên: 21/02/2014, 03:20

... Motion of the Ca 2+ -pump captured Masatoshi Yokokawa 1,2 and Kunio Takeyasu 1 1 Kyoto University Graduate School of Biostudies, Japan 2 Graduate School of Pure and Applied Science, University of ... 2011) doi:10.1111/j.1742-4658.2011.08222.x Studies of ion pumps, such as ATP synthetase and Ca 2+ -ATPase, have a long history. The crystal structures of several kinds of ion...

Ngày tải lên: 14/02/2014, 14:20

... constitutes one of the major aspects of hepatocyte function and contributes to the metabolism and elimination of exogenous and endogenous sub- stances [4]. In various models and in clinical reports, Keywords CYP450; ... serum con- centrations of tumor necrosis factor-a and interleukin-6, and increased hepatic mRNA levels of tumor necrosis factor-a and interleukin-6 wer...

Ngày tải lên: 14/02/2014, 18:20

... our understanding of the importance of different parts of the molecule and their flexibility in the process of amy- loid fibril formation often results more from a struc- tural analysis of the amyloid ... [120] and by heteronuclear NMR (human stefin A and chicken cystatin) [121,122]. The domain-swapped dimer of stefin A (Fig. 2A) is made of strand 1, the a-helix and strand 2...

Ngày tải lên: 14/02/2014, 18:20