... & Nakai A (2005) Active HSF1significantly suppresses polyglutamine aggregate forma-tion in cellular and mouse models. J Biol Chem 280,34908–34916.97 Steele AD, Hutter G, Jackson WS, Heppner ... Drosophila, the HSF1 is required for the heat shock response, whereas HSF3 is required for this response in avian species [8,9]. Both mouse HSF1and chicken HSF3 are necessary for thermotolerance,at ... q24.3 and mouseChr.15 D3 for HSF1; human Chr.6 q22.31,mouse Chr.10 B4 and chicken 63.95–63.98 Mb for HSF2; human Chr. X q12,mouse Chr. X B4 and chicken 0.252–0.265 Mb for HSF3; and human Chr.16q22.1,...