Tài liệu Báo cáo khoa học: "Structural Definition of Affixes from Multisyllable Words" docx

... 1966] Structural Definition of Affixes from Multisyllable Words by Lois L. Earl,* Lockheed Missiles and Space Company, Palo Alto, California In a recent paper by H. L. Resnikoff and J. L. Dolby, ... "The Nature of Affixing in Written English," an algorithm for the structural definition of affixes was developed and applied to data consisting of all the words of the form CVCVC ... the affixes could not be ex- pected to show up in two-vowel-string words. This paper summarizes the results of applying a modified form of the operational definition to data consisting of all...

Tài liệu Báo cáo khoa học: Structural features of proinsulin C-peptide oligomeric and amyloid states pptx

... widerange of spectroscopic techniques.Suitable methods for investigation of the secondarystructure and morphology of such structures, however,require the presence of large amounts of the oligomericstate, ... distribu-tion of 100 lM proinsulin C-peptide in thepresence of divalent Ca2+and Mg2+ionsunder native conditions (B), and of 100 lMC-peptide in the presence of insulin (C) and of 100 lM ... population of monomerswith a hydrodynamic radius of approximately 16 A˚,which is in agreement with the results of the NMR.The addition of SDS to the C-peptide sample leads toformation of larger...

Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx

... the geometry of theactive site. The availability of crystal structures of TIMs from 21 sources and the large database of TIMsequences from various sources facilitate an analysis of mutational ... conse-quences of mutations. In the case of TIM, only nine of the 220–250 residues present in the sequences of theenzymes from diverse sources are indeed completelyconserved. A relatively small number of ... 2009 FEBS 4173one member of this class is available, from Giar-dia lamblia [29]. A comparison of the immediate envi-ronment of residue 74 in the structures of TIMs from yeast, P. falciparum...

Tài liệu Báo cáo khoa học: Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide pdf

... 1.2 molar ratio of Ca2+⁄ CaM to PhK5had been reached. The inset shows an expanded view of the indi-cated area of the spectrum. (Bottom) An overlay of spectra from the titration of Ca2+⁄ CaM ... againstFig. 4. (Top) Overlay of two spectra from the titration of Ca2+⁄ CaMwith PhK5 peptide. The red spectrum shows the position of peaksprior to the addition of PhK5 peptide. The blue spectrum ... mole-cule of CaM that binds to the enzyme even in theabsence of Ca2+[2]. The regulation of PhK throughCa2+⁄ CaM enables the coordination of muscle contrac-tion with the production of glucose...

Tài liệu Báo cáo khoa học: Quantitative estimation of channeling from early glycolytic intermediates to CO2 in intact Escherichia coli pdf

... highdegree of channeling of fructose 1,6-bisphosphate(Fru1,6P2)toCO2(99 ± 16% of the ﬂux from Fru1,6P2channeled, P ¼ 0.005). This result requiresthat all of the downstream steps from Fru1,6P2topyruvate ... rate of the evolution of 14CO2 from the earliesttime point (see Results). Also recall from the Resultsthat the CO2evolved from [14C]glucose was strictlyproportional to the total uptake of ... regulation of metabolism. Whereasthe usual mechanism proposed for channeling is the (often) transient inter-action of sequential pathway enzymes, many of the supporting data come from results...

Tài liệu Báo cáo khoa học: "The Nature of Affixing in Written English" docx

... problem of unscrambling English affixes. The role of affixes is crucial in the study of word-breaking practice. In the automatic determination of the parts of speech (a central feature of automatic ... essence of the problem of the definition of 'affix' lies here. It is not too hard to construct a sufficiently broad and inclusive definition; the construction of an effective definition ... typical of the new affixes pro- duced by the relaxed definition. We take the view that the difference between affixes and compounding units is not one of kind, but one of degree: affixes...

Tài liệu Báo cáo khoa học: Crystal structure of an ascomycete fungal laccase from Thielavia arenaria – common structural features of asco-laccases ppt

... surface of the molecule and is ratherfar away from the trinuclear site. Therefore, theC-terminal sequence of RlL might be more of an evolu-tionary relic than a functional feature of the enzyme.The ... at pH levels ranging from 2 to 8.AcknowledgementsWe are grateful to M. Paloheimo from Roal Oy forproviding us with samples of TaLcc1. The ESRF isthanked for provision of synchrotron facilities. ... Academy of Finland (Project 115085)supported the work at Joensuu, and part of the VTTwork was carried out with ﬁnancial support from theMarie Curie EU-project ‘Enzymatic tailoring of pro-tein...

Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

... consequences of having HPRT deﬁciency are an overproduction of uric acid and elevated levels of PRPP [3]. Patients hav-ing mutations resulting in partial HPRT deﬁciencyoften suffer from gouty ... elucidation of the structure of PRTFDC1and the deﬁnition of its ligand binding speciﬁcity from a large metabolome library provides an initial startpoint for deﬁning the molecular function of PRTFDC1. ... and scaled using scala from theccp4 software suit [30]. The structure was solved with themolecular replacement software molrep [31] using coordi-nates from a monomer of HPRT (Protein Data Bank...

Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of ﬂavoproteins: electron transfer through the nitric oxide synthase ﬂavoprotein domain pdf

... function of the rates of con-formational change (k1, k2) that determine KeqA. How-ever, when the rate of conformational change begins toapproach the rate of FMNH2formation (either from speeding ... assessment of the relative importance of conformational changerates versus rates of FMNH2formation in limiting elec-tron ﬂux through the CaM-bound NOS enzymes. Ingeneral, as the konand koff of ... ﬂuorescence intensity of the oxidized ﬂavins, the interaction of bound FMNH•with a soluble paramagnetic agent by EPR spectros-copy, and rates and extent of reaction of boundFMNH2(FMNH))...

Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of ﬂavoproteins: probes of hydrogen tunnelling pptx

... Mathematical theory of the kinetics of the coagulation of colloidal solutions.Z Phys Chem 92, 129–168.64 Ansari A, Jones CM, Henry ER, Hofrichter J & EatonWA (1992) The role of solvent viscosity ... to study the viscosity dependence of the rate of hydride transfer in GO [70,71]. These authors studiedvarious glycoforms of the enzyme (varying in theextent of glycosylation) [70] and also replaced ... of rates and kinetic isotope effects using PEG-modiﬁedvariants and glycoforms of glucose oxidase: therelationship of modiﬁcation of the protein envelopeto C–H activation and tunneling. Biochemistry...

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