Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf

... further investigate the role of the SEA domain in cleavage of membrane-tethered mucins we carried out site-directed mutagenesis of the FRPG ⁄ SVVV site and evaluated hybrid mucins in which the SEA ... of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins Timea Palmai-Palla...

Ngày tải lên: 19/02/2014, 18:20

... mechanism of antitumour action of BS-RNase is based on the ability of the protein to resist the neutralizing action of the cytosolic RNase inhibitor, a resistance due to the dimeric structure of the enzyme. ... that link the two subunits of BS-RNase. Monomeric derivatives of the protein are inactive as cytotoxic agents when they are prepared by reductive cleavag...

Ngày tải lên: 20/02/2014, 11:20

... in obese mice In order to gain insights into the potential biologically relevant role of miR-27 in the regulation of adipose tis- sue functions in vivo, we examined the expression of miR-27 in ... together, these results illustrate a critical and specific role of miR-27 in the regulation of adipogenic differentiation. miR-27 prevents the induction of PPA...

Ngày tải lên: 18/02/2014, 08:20

... molecule comprising Ôresidues in the protruding domain consisting of the type VI b-turn and the first part of b-strand 3Õ (i.e. the b-hairpin loop and part of the adjoining b-sheet) and Ôresidues in the loop ... obtained by other groups who also point to the role of the connecting loop of the b-hairpin of defensins. A combination of mutational analys...

Ngày tải lên: 20/02/2014, 11:20

... deviates from the original position. In the struc- tural deviation, the solvent ASA of the side-chain of His210 increased with the decrease in size of the side-chain at residue 169 (Table 1 and Fig. ... effect of the size of the residue at position 169 may be related to the solvent accessibility of the side-chain of His210 (Fig. 3C). When the accessib...

Ngày tải lên: 21/02/2014, 03:20

... are used. We evaluated the influence of context by varying both the position and the size of the win- dow of words (i.e., parts of speech) surrounding the candidate compound. The window size param- eter ... corpus independently of their posi- tion (i.e., independently of whether they are heads or modifiers). Consider the compounds cocaine customer and baby calf...

Ngày tải lên: 22/02/2014, 02:20

... at higher levels in testes than ovaries. The deep interest in Dmrt1 in the field of sex deter- mination in fish came with the discovery of a dmrt1 homologue on the Y chromosome of the fish medaka (Oryzias ... of Sry is translated into cellular structure and organ morphology. Interestingly, Dmrt1, the ancestor of Dmrt1bY, is one of the downstream effec- tors o...

Ngày tải lên: 14/02/2014, 19:20

... from the National Basic Research Program of China (2007CB512007), the National Natural Science Foundation of China (30700290) and Special Funds for PhD Training from The Ministry of Education of ... oxidative stress induces nucleolin ⁄ C23 cleavage and apoptosis [14], and that nucleolin downregulation induces apop- tosis in C2C12 cells [15]. These data suggest the ro...

Ngày tải lên: 16/02/2014, 09:20

... dieu da dugc dh dinh sdn; phai the hien cbinh xdc sdc thai thong tin Mgt sy ngdt nghi khong ddng ldc, diing cbd, mdt tdc do re ra, chdm chap ttong Bin tin chung khoan. Bin tin thi thao. mdt ... "Dpe lip din tpc gin lien vdi chu nghia xahpi" do Hoing Yin thi hiin. Gipng dpe hap din, nghe mach lac. On ip, quyin rd hii sdc, giy hiing thu cho thinh gii khdng chi...

Ngày tải lên: 17/02/2014, 05:20

... containing the mutations of the miR-23a binding site (Fig. 4A). It was shown that miR-23a ASO or pcDNA3 ⁄ pri-23a did not affect the intensity of EGFP fluorescence in the vector bearing the mutant ... interacts with the first potential binding site of the IL6R mRNA 3¢ UTR. (A) The three EGFP reporter vectors bear- ing mutations of the miR-23a seed region binding site...

Ngày tải lên: 18/02/2014, 04:20