Tài liệu Báo cáo khoa học: cN-crystallin and the evolution of the bc-crystallin superfamily in vertebrates pdf

Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

... N7 (Fig. 1C). The 2¢OH of the ribose is hydro- gen bonded to the main chain and the side chain of Asp142 (Fig. 1C). Both hydroxyl groups of the ribose are involved in coordinating a putative ... solutions. The ligand bound was interpreted as GMP because the N2 of the base makes a hydrogen bond to a main chain car- bonyl. Binding of a xanthine base from XMP in...
Ngày tải lên : 15/02/2014, 01:20
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Tài liệu Báo cáo khoa học: Structure and membrane interaction of the internal fusion peptide of avian sarcoma leukosis virus pdf

Tài liệu Báo cáo khoa học: Structure and membrane interaction of the internal fusion peptide of avian sarcoma leukosis virus pdf

... on the N-terminal FP, it would be of interest to compare the structure of the internal FP and i ts interaction w ith membrane bilayer, including in particular the structural in uence of proline. ... into the target membrane in the fusion process [10,11]. In the following, a variety of physical properties of the putative IFP of ASLV are reported and diffe...
Ngày tải lên : 19/02/2014, 16:20
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Tài liệu Báo cáo khoa học: Bioinformatic and enzymatic characterization of the MAPEG superfamily doc

Tài liệu Báo cáo khoa học: Bioinformatic and enzymatic characterization of the MAPEG superfamily doc

... E. coli and Synechocystis sp. bacteria further, to gain insight into the function of these proteins and the evolution of the MAPEG superfamily. Cloning and overexpression demonstrated that both ... E.coliMGST cluster and SynMGST cluster). A major subgrouping is visible with MGST1, PGES and Insect in the upper part of the tree and the remaining families ⁄ gro...
Ngày tải lên : 19/02/2014, 17:20
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Tài liệu Báo cáo khoa học: Biochemical and molecular characterization of hazelnut (Corylus avellana) seed lipoxygenases pdf

Tài liệu Báo cáo khoa học: Biochemical and molecular characterization of hazelnut (Corylus avellana) seed lipoxygenases pdf

... for the synthesis of leukotrienes and lipoxins belonging to the eicosanoid family which are involved in many physiological processes [1]. In plants the biosynthesis of phytooxylipins is initi- ated ... providing the substrates for the activity of all the enzymes located downstream on the pathway, have a primary role in the biosynthesis of phytooxylipins and c...
Ngày tải lên : 21/02/2014, 00:20
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Tài liệu Báo cáo khoa học: Functional and structural analyses of N-acylsulfonamidelinked dinucleoside inhibitors of RNase A ppt

Tài liệu Báo cáo khoa học: Functional and structural analyses of N-acylsulfonamidelinked dinucleoside inhibitors of RNase A ppt

... [46]. The similarity in the K m values is attributable to the uracil moiety binding in the same fashion [38], which could trigger the initial binding of both substrates. In UpG, the binding of the guanine ... studies of the structure and binding sites of enzymes. 8. Inhibitor binding to ribonucleases. J Mol Biol 45, 491–511. 33 Ui N (1971) Isoelectric points a...
Ngày tải lên : 14/02/2014, 22:20
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Tài liệu Báo cáo khoa học: Active and regulatory sites of cytosolic 5¢-nucleotidase doc

Tài liệu Báo cáo khoa học: Active and regulatory sites of cytosolic 5¢-nucleotidase doc

... only the amino acid residues involved in the binding of the purine base were identified, while the ribose moiety was completely disordered [11]. Mutation of two residues involved in the binding of adenine ... sites 1 and 2 and involved in bind- ing of adenylic nucleotides and BPG. Our results partially confirm the molecular model- ling, suggesting that effector s...
Ngày tải lên : 15/02/2014, 01:20
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Tài liệu Báo cáo khoa học: Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion pptx

Tài liệu Báo cáo khoa học: Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion pptx

... Yersinia surface protein invasin binds to b1 integrins on the apical surface of M cells, which facilitates translocation across the epithelium [4,5]. The pathogenicity and virulence of Yersiniae ... threonine kinase that phosphorylates actin [12], binds the deubiquitinat- ing enzyme otubain 1 (OTUB1) [13,14], the small G protein subunit Gaq [15] and interacts with mem- bers...
Ngày tải lên : 16/02/2014, 15:20
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Tài liệu Báo cáo khoa học: Isolation and molecular characterization of a novel D-hydantoinase from Jannaschia sp. CCS1 docx

Tài liệu Báo cáo khoa học: Isolation and molecular characterization of a novel D-hydantoinase from Jannaschia sp. CCS1 docx

... analysis of substrate on the active site of HYD Js The substrate binding pocket in the active site was inves- tigated based on the homology model to obtain more information on substrate binding in ... (B) The SGLs of HYD Bp are shown as magenta lines and those of HYD Js are shown in green. The transition state of D-p-HPH is shown in turquoise, and the four...
Ngày tải lên : 18/02/2014, 08:20
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Tài liệu Báo cáo khoa học: Post-translational modifications of the linker histone variants and their association with cell mechanisms docx

Tài liệu Báo cáo khoa học: Post-translational modifications of the linker histone variants and their association with cell mechanisms docx

... agree- ment about the overall parameters of the fibre formed by folding the zig-zagging chain of nucleosomes in inactive chromatin, the location of the linker histone in relation to the nucleosome ... ubiquitinated in H1.2, H1.3 and H1.4 in human HeLa cells, but not in MCF7 cells. In mouse tissue, Lys116 of H1.1 and Lys46 of H1.2 and H1.3 in the sple...
Ngày tải lên : 18/02/2014, 08:20
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Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain pdf

Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain pdf

... extents in the FNR–FMN subdo- main interface, including the interface in NOS (Fig. 8). Point mutations that neutralize charge pairing or intro- duce charge-repelling interactions may increase the Fig. ... rate [111–114]. The FMN–FNR sub- domain hinge (H1 in Fig. 5) is one of the least con- served motifs and is shorter in eNOS than in nNOS. Swapping the H1 hinge of...
Ngày tải lên : 18/02/2014, 11:20
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