Tài liệu Báo cáo khoa học: The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression ppt

... 12, 5191–5200. The RRM domain, a plastic RNA- binding platform C. Maris et al. 2130 FEBS Journal 272 (2005) 2118–2131 ª 2005 FEBS MINIREVIEW The RNA recognition motif, a plastic RNA- binding platform to regulate ... clear why these RRM domains that are very similar to the classical ones favor interaction with proteins rather than RNA. Conclusion and perspecti...

Ngày tải lên: 19/02/2014, 17:20

... private Foundation (Exp: 36557⁄ 06) and Generalitat Valenci- ana (ACOMP ⁄ 2009⁄ 185). Drs Mauricio G. Mateu and Francisco N. Barrera are thanked for critically reading the manuscript and for their ... del Carmen Lidon-Moya and Estefanı ´ a Hurtado- Go ´ mez are acknowledged for their careful experimental work. May Garcı ´ a, Marı ´ a del Carmen Fuster, Javier Casanova and Olga Ruiz de...

Ngày tải lên: 18/02/2014, 06:20

... benzo [a] pyrene-2¢-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases Oksana M. Subach 1 , Diana V. Maltseva 1 , Anant Shastry 2 , Alexander Kolbanovskiy 2 , Saulius ... (+)-trans-B [a] P-N 2 -dG. GCG ref 5¢-GAGCCAAGCGCACTCTGA CGM ref 5¢-TCAGAGTGMGCTTGGCTC GCG 5¢-CACCCTTGCGCTCTCTCA CGC 5¢-TGAGAGAGCGCAAGGGTG CGM 5¢-TGAGAGAGMGCAAGGGTG X + CG 5¢-CACCCTTX + CG...

Ngày tải lên: 19/02/2014, 00:20

... family The nuclear lamina is a complex ensemble of proteins that connects the inner nuclear membrane to chroma- tin, and thus creates a link from the cytoplasm to the genome. The nuclear lamina has ... proteins and chromatin associating factors. The constituent proteins, the lamins, have recently gained tremendous recognition, because mutations in the lamin A gene,...

Ngày tải lên: 19/02/2014, 02:20

... subunit mutations are both sensitive and resistant to volatile anesthetics. Anesth Analges 95, 578–582. 38 Takasaki M, Tatara T, Suezaki Y, Shirahama K, Kamaya H, Ueda I & Totoki T (1991) Effect of inhala- tion ... molecular targets are most relevant to general anaesthesia? Toxicol Lett 100–101, 1–8. 17 Mihic SJ, Ye Q, Wick MJ et al. (1997) Sites of alcohol and volatile anaesthetic ac...

Ngày tải lên: 19/02/2014, 18:20

... the reparandum and the repair. Example (3) shows the crossing dependencies. As this exam- ple also shows, the repair often contains many of the same words that appear in the reparandum. In fact, ... Y]. ∂E[e]/∂w j is given by a similar formula. 9 Results We follow Charniak and Johnson (2001) and split the corpus into main training data, held-out train- ing data and test data a...

Ngày tải lên: 20/02/2014, 04:20

... so-called bias. The basic idea is to take advantage of misclassified examples in the training data to iteratively refine and adjust the centroids of text data. The experimental results reveal ... classifier using the binar y class (0 and 1) over the total training data. TESTING 1 Apply each of the L classifiers to the test example. 2 Assign the test example th...

Ngày tải lên: 20/02/2014, 12:20

... of the RNAi ⁄ miRNA pathway, which carry an RNase domain for dsRNA cleavage and pro- cessing [12–14]. A second group of dsRBM-containing proteins do not carry an identifiable catalytic domain. ... interactions, thus adding an additional regulatory layer to dsRBM RNA recognition. Interaction with non-dsRNA partners Although dsRNA-binding is the defining feature of dsRBMs, other macrom...

Ngày tải lên: 19/02/2014, 17:20

... ⁄ PAGE. Purification was performed at 4 °C. The supernatants were concentrated through a hollow fiber cartridge (cutoff 6 kDa; Motianmo, Tianjin, China) and the His-tagged proteins in the supernatants were adsorbed ... Protein concentration was determined using the Bradford assay with BSA as the standard [28]. Phytase activity assay Phytase activity was determined by measuring the...

Ngày tải lên: 14/02/2014, 15:20

... in an extended conformation. Database Structural data are available in the protein Data Bank under the accession number 3OQS. Structured digital abstract l CLIC4 and importin alpha bind by x-ray ... The CLIC4 NLS binds in an extended conformation that runs antiparallel to impor- tin -a, analogous with other NLS cargo. The average atomic B factors for importin -a in the structure...

Ngày tải lên: 14/02/2014, 19:20