Tài liệu Báo cáo khoa học: Liver X receptor agonists inhibit tissue factor expression in macrophages docx

... (COX-2) and MMP-9. In this study, we investigated whether LXR activation inhibits inducible TF expression and activity in macrophages. Results LXR agonists inhibit TF expression induced by in ammatory ... Recently, LXR agonists have been reported to repress expression of in ammatory genes such as iNOS, COX-2 and MMP-9 in macrophages [19,20]. In this study, we also fo...

Ngày tải lên: 19/02/2014, 17:20

... 2005), information retrieval (Finkelstein et al., 2002), information extraction pattern induc- tion (Stevenson & Greenwood, 2005), interpretation of noun compounds (Kim & Baldwin, 2005), ... ex- tensive review). For instance, Rada et al. (1989) traverse MeSH, a term hierarchy for indexing ar- ticles in Medline, and compute semantic related- ness straightforwardly in terms of the n...

Ngày tải lên: 20/02/2014, 12:20

... acid; GCDA, glycochenodeoxycholic acid; I-BABP, human ileal bile acid-binding protein; iLBP, intracellular lipid-binding protein; L-BABP, chicken liver bile acid-binding protein. FEBS Journal 276 ... positioning of helix II in the two complexes. Arg32, characterized by high T 1 ⁄ T 2 values in the apo protein and in all of the investigated holo proteins, thus plays a key role in reg...

Ngày tải lên: 18/02/2014, 06:20

... participating Table 1. Amino acid frequencies (%) in a-amylase linkers, in a set of globular proteins, in the Swiss-Prot databank and in intrinsically unstructured proteins. Amino acid Linkers a Globular proteins b Swiss-Prot c Intrinsically unstructured proteins b Ala ... the ring may sterically disfavor extensive bending in this region, which could result in unwanted interaction...

Ngày tải lên: 14/02/2014, 18:20

... of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis: an increase in lamin A ⁄ C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced ... of β β -Actin α -Synuclein Fig. 1. Relative expression of a-synuclein in b-gal and a-syn cells in response to dopamine (DA) treatment. Results are indicated as the fold of i...

Ngày tải lên: 15/02/2014, 01:20

... have included a full list of N-glycopro- teins from C. elegans and a partial list from mouse liver containing the protein (gene) ID, protein name, glycosy- lated sites, and kinds of lectins used ... proteins that carry an epitope bound by a specific lectin (stage III). The abundance of each glycoprotein in serum was esti- mated by IGOT using Ricinus communis agglutinin 120 (RCA120), which...

Ngày tải lên: 16/02/2014, 08:20

... the Astrocyte Exocytosis Cl – channels P 2X7 receptors P2Y1,P2Y2 Maxi-anion channels Connexin/pannexin hemichannels N Gq PLC ATP, ADP, UTP ER Ca 2+ C Ins(1,4,5)P 3 Ins(1,4,5)P 3 -R A B Fig. 2. P2 receptors ... in the formation of Ins(1,4,5)P 3 , leading to Ca 2+ release from Ca 2+ stores. (B) Multiple pathways for the release of ATP. Hemichannels of connexin or pannexin, maxi-anion channel...

Ngày tải lên: 16/02/2014, 09:20

... acti- vating E2Fs cooperate with NF-Y proteins binding to CCAAT-boxes and with Myb proteins associating with a distal Myb site in activating the Cdc2 promoter. Binding of the activating E2Fs during ... as cyclin A and cyclin B1, in dividing cells [92]. Furthermore, depletion of Lin-9 and B-Myb in p53 ) ⁄ ) MEFs caused lowered expression of cyclin A, cyclin B and Cdc2 [94]. In simila...

Ngày tải lên: 16/02/2014, 09:20

... translocation domain (T domain) and the receptor- binding domain. The C and T domains remain covalently linked by a disulfide bond. Following binding to its cell-surface receptor, diphtheria toxin is internalized ... chain of 58 kDa [1]. During cell intoxication, diphtheria toxin is cleaved by furin into two fragments: the A chain corresponding to the catalytic domain (C domain); and the B c...

Ngày tải lên: 16/02/2014, 09:20

... lgÆmL )1 (lines 4–6). (C) Increased binding of pH 4 buffer- exposed IVIg to recombinant human IFN-c. (D) Increased binding of low-pH buffer-exposed IVIg to human factor H. In both panels, binding of ... distances (x- axis) expressed in pixels were plotted against the intensity of binding (y-axis) expressed in relative units (RU) for each IVIg preparation. (B) Reactivity of native (lin...

Ngày tải lên: 16/02/2014, 15:20