Tài liệu Báo cáo khoa học: Effect of gadolinium on the ryanodine receptor/ sarcoplasmic reticulum calcium release channel of skeletal muscle docx

... with the gadolinium ions if they get through the channel. The affinity of the Gd 3+ compared to the EGTA is a million-fold larger than that of the Ca 2+ Fig. 6. Effect of gadolinium on the calcium ... 0.42. Discussion The effect of Gd 3+ was investigated on the function of SR Ca 2+ release channel ⁄ ryanodine receptor complex. When the [ 3 H ]...

Ngày tải lên: 19/02/2014, 16:20

... separately for the beginning of the first (left) and end of the sec- ond (right) phrases of the candidate fact. For gen- erality, the computation relies only on the part- of- speech tags of the current ... distinguish the quality of extraction patterns based, for instance, only on the percent- age of the seed set that they extract. The second reason is t...

Ngày tải lên: 20/02/2014, 12:20

... Dicer knockdown on the silencing efficacy of mismatched siRNAs We hypothesized that the reduction in the function of the mismatched siRNAs was a consequence of impaired interactions with TRBP and ... essentially the same silenc- ing capacity as in the presence of TRBP, actually becoming the most active of all the siRNAs under these conditions (Fig. 2A). In contrast,...

Ngày tải lên: 18/02/2014, 06:20

... the closed conformation. The only other P-loop move- ments that have been observed in PTPs are a result of oxidation of the catalytic cysteine. Sensitivity of PhyAsr to oxidation The low pK a of the ... closed P-loop conformation is stable over a broad ionic strength range. Structure of PhyAsr upon oxidation of the catalytic cysteine A systematic comparison of the...

Ngày tải lên: 18/02/2014, 18:20

... demonstrated the essential role of this region in the transcription of the Ig-b gene. Deletion of region III decreased the expres- sion of Ig-b mRNA to 40% of the expression in prede- letion cells ... deletion (16 kb Del) in one allele of the Ig-b locus (Fig. 1). Introduction of the 16 kb Del construct into DT40 ⁄ Cre cells resulted in two deletion clones. In one...

Ngày tải lên: 19/02/2014, 16:20

... under low ionic strength conditions [8,44]. However, this effect is not seen in the kinetics of the MA/CA hydrolysis. In the high ionic strength of the assays the dimerization is strengthened as ... PR inhibitor therapy, soon after the appearance of one (or a few) critical PR mutations, therefore we have characterized the effect of single protease mutations in respon...

Ngày tải lên: 21/02/2014, 03:20

... translation knowledge in order for it to be used in the real world situ- ation. One limitation of the corpus-based trans- lation knowledge acquisition approach is that the techniques of translation ... reduction with the help of cross-language retrieval of relevant texts is quite effective in improving the performance of precise estimation of bilingual term correspondenc...

Ngày tải lên: 22/02/2014, 02:20

... thetase to esterify the 13cROL generated in the reac- tion. Therefore, 13cROL is accumulated in the absence of LRAT in the reaction (Fig. S3B). Under the in vitro assay conditions of the ... substrate under the same reaction conditions and extraction procedures. The peak of each retinoid iso- mer was identified based on its characteristic retention time and the absorp...

Ngày tải lên: 14/02/2014, 14:20

... position. A comparison of the structure of the unli- ganded cathepsin B with the structure of the proenzyme, its complexes with chagasin and stefin A shows that the magnitude of the shift of the ... adopt a variety of con- formations, whereas the rest of the structure of cathep- sin B appears to be rigid. A comparison of the interaction constants of the...

Ngày tải lên: 18/02/2014, 04:20

... included in the pub- lished alanine scanning mutagenesis study of FVIIa [13], and investigated the effects of the mutation on the enzymatic maturation of FVIIa and on the response of FVIIa to ... two of the components of the invisible scaffold supporting the active conformation. One bond participates in stabil- ization of the 170 loop while the other conn...

Ngày tải lên: 18/02/2014, 08:20