... and a negative regulator of blood coagulation,acting as a cofactor for activated protein C in the deg-radation of clotting factors Va and VIIIa [5]. Gas6 has the same domain organization as ... L1273–L1281.18 Nakamura YS, Hakeda Y, Takakura N, Kameda T,Hamaguchi I, Miyamoto T, Kakudo S, Nakano T,Kumegawa M & Suda T (1998) Tyro 3 receptor tyro-sine kinase and its ligand, Gas6, stimulate the ... RTKs participate in a signalling axis oftenreferred to as the Gas6–Axl system, Gas6 being the lig-and. Since the discovery of Axl in 1991, a tantalizingassortment of roles for the Gas6–Axl system...