Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt

... diagram of crystal structure o f CD2 CD58 complex and crystal structure of rat CD2. (A) Ribbon diagram of crystal structure of CD2 CD58 (LFA-3) complex. Starting positions of peptides for docking ... tructure of the surface epitopes of the CD2 protein. Docking studies of CD2 peptides and CD58 protein revealed the possible binding sites of the cyclic...

Ngày tải lên: 19/02/2014, 13:20

... Fragments of HSQC and HMBC spectra of compound 1. Labels illustrate assignment of the amide linkage between the amino group of Asp and the carboxyl group of GalA residue E. Scheme 1. The structures of ... 85 °Cfor 30 min), dried and analyzed by GC-MS with the standards prepared from D -GalN and (R)- and (S)-2-BuOH. The absolute configuration of L -aspartic acid was dete...

Ngày tải lên: 19/02/2014, 16:20

... absence of a lipoprotein is confirmed by the absence of TLR2 reactivity in the CHO reporter system (Fig. 7), which has been shown to be responsible for signaling in the case of lipopeptides and lipoproteins ... were performed. 3272 K. Brandenburg et al. (Eur. J. Biochem. 270) Ó FEBS 2003 Aggregate structures and molecular shape For the determination of the three-dimensional sup...

Ngày tải lên: 21/02/2014, 00:20

... The Structure and Process of Talking About Doing James A. Levln and Edwin L. Hutchins Center for Human Information Processing University of Callfornia, San Diego People ... study of problem solving action and report: I) the collected of data on problem solving and talk about problem solving, 2) development of a process model of these behaviors, and 3) use of...

Ngày tải lên: 21/02/2014, 20:20

... truncated isoform. Cloning of the cDNA of two isoforms of tomato b-fructofuranosidase and recombinant expression in E. coli For protein expression in E. coli, only the cDNA coding for the mature proteins ... specific 5¢ -and 3¢ primers selected on the basis of the published sequences for tomato b-fructofuranosidase (GenBank accession no. D11350 and S70040). Primers for t...

Ngày tải lên: 21/02/2014, 00:20

... the T. brucei and T. cruzi proteins. These K d values actually represent the ligand affinities for a nonactive conformation of the enzyme in the absence of substrate and cofactor. Molecular ... further the behaviourofbothproteinswithregardtothesesubstrate analogues. Inhibition and site-directed mutagenesis of T. brucei gGAPDH In the absence of a 3D structure of a complex...

Ngày tải lên: 20/02/2014, 02:21

... crystal structure, molecules A and B (and C and D) of the asymmetric unit form a weak dimer (Fig . 6). On the basis of calculations performed Fig. 6. (A) Cartoon representation of dimers of TaLcc1 ... analogous structures of the ascomycete laccase (asco-laccase) MaL, thus giv- ing a comprehensive view of the structure and function of asco-laccases. Results and Discu...

Ngày tải lên: 14/02/2014, 18:20

... rearrangement of CLIC4, and provides a trigger for NLS conforma- tional change, requires further investigation. The possibility of trigger events to expose NLSs offers an interesting criterion for cargo ... cargo proteins destined for the nucleus, it is likely that importin-a screens additional criteria, such as the flexibility of the NLS and its solvent exposure within a folde...

Ngày tải lên: 14/02/2014, 19:20

... (Fig. 3A). Three of the ligands, OD2 of Asp165, NE2 of His79 and NE2 of His169, formed an equatorial plane. The other protein ligand, NE2 of His31, bound to the metal, in the company of a water oxygen, ... polypeptides consisted of seven a-helices, a three-stranded antiparallel b-sheet and loops connecting these secondary structure elements. The con- tents of the a-hel...

Ngày tải lên: 14/02/2014, 22:20

... a conformational change of this region of PhyK is not very likely. Because the elongated a helix A was observed in all six protein molecules of this study (two in the structure of PhyK and four ... R work of 0.190 and R free of 0.224. This model was used as search model for molecular replacement with the native data with a resolution of 1.68 A ˚ . Iterative cycles of...

Ngày tải lên: 16/02/2014, 09:20