Tài liệu Báo cáo khoa học: Combinatorial approaches to protein stability and structure pdf

... understand what makes proteins ÔtickÕ andtoengineer proteins with native-like properties. In this review we discuss combinatorial approaches toward understanding protein structure and stability. ... (barnase) and 1YPI (yeast TIM). Ó FEBS 2004 Combinatorial protein biophysics (Eur. J. Biochem. 271) 1601 MINIREVIEW Combinatorial approaches to protein stability and...

Ngày tải lên: 19/02/2014, 12:20

... PTMs, protein glycosylation is the most pre- valent and diverse [11,12]. The glycans on proteins play key roles in expression and folding [13], thermal and proteolytic stability [14], and cellular ... vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photo- receptor structure. J Cell Biol 130, 431–439. 65 Cozzone AJ (2005) Role of protei...

Ngày tải lên: 18/02/2014, 17:20

... MINIREVIEW Computational approaches to understand a-conotoxin interactions at neuronal nicotinic receptors Se ´ bastien Dutertre and Richard J. Lewis Institute for Molecular Bioscience, University of Queensland, ... Brisbane, Queensland, Australia Recent and increasing use of computational tools in the field of nicotinic receptors has led to the publication of several models of ligan...

Ngày tải lên: 19/02/2014, 12:20

... binding to this crystallin by ITC and determined the binding constant for the calcium mimic probe. Terbium is believed to bind strongly to calcium-binding sites of proteins compared to calcium due to ... mm KCl and 1 mm dithiothreitol. Fractions containing the pure protein were collected and buffer exchanged with Chelex- treated buffer to remove calcium. Proteins were eith...

Ngày tải lên: 18/02/2014, 16:20

... proteins, such as cytochrome c, which are released into the cytoplasm as a consequence of apoptotic signals. The release of these apoptotic factors involves alteration of the mitochondrial outer membrane ... this protein is normally found soluble in the cytoplasm, its apoptotic activation includes extensive structural reor- ganization, which facilitates targeting to, and insertion into,...

Ngày tải lên: 19/02/2014, 07:20

... as alimentary toxic aleukia (ATA) and stachybotryotoxicosis. In this study, cytotoxicity and genotoxicity of T-2 toxin was investigated in vitro on Vero cell line using the MTT and the neutral ... and 868 controls. Combining genomic and proteomic techniques, differences in gene and protein expression profiles from HNSCC and normal counterparts and their relations to clinica...

Ngày tải lên: 19/02/2014, 07:20

... sentences where the tokenization differs, and also in the total Levenshtein distance (Leven- shtein, 1966) over tokens (for a total of 49,208 sen- tences and 1,173,750 gold-standard tokens). Looking ... modifications to the text, lemmatising expres- sions such as won’t as will and n’t. 4 REPP: A Generalized Framework For tokenization to be studied as a first-class prob- lem, and to...

Ngày tải lên: 19/02/2014, 19:20

... related to the handling of lexical and structural ambiguities by human parsers. Its theory of communication and the arbi- tration mechanism can explain data that modular theories of syntax and ... Research, 20(3):233-250. Kurt P. Eiselt, Kavi Mahesh, and Jennifer K. Hol- brook. 1993. Having Your Cake and Eating It Too: Autonomy and Interaction in a Model of Sentence Pro...

Ngày tải lên: 20/02/2014, 21:20

... that automatically learns to predict/suggest the grammatical constructs and lexical translations expected to immediately follow the current translation given a source text, and adapts to the ... text S and its translation prefix T p into character-level and 3 Inspired by (Gamon and Leacock, 2010). word-level ngrams respectively. Step (3) and (4) retrieve the tran...

Ngày tải lên: 22/02/2014, 03:20

... BTK–SYK and ITK– SYK fusion proteins lead to differential phosphorylation levels of the fusion proteins themselves, as well as the downstream adapter proteins SLP76 and BLNK, in 293T and COS7 ... transgenic mice, the ITK– SYK fusion was found to translocate to lipid rafts and was able to constitutively phosphorylate T-cell recep- tor-associated signaling proteins. It is notewo...

Ngày tải lên: 14/02/2014, 18:20