... presence of this enzyme in different tissues with properties of endothelial NOS, nNOS, and ⁄ or iNOS [14,31,32]. Indifferent models of sepsis and tissues, the existence of both mtNOS and i-mtNOS isoforms ... synthesis by NOS,leading to formation of the BH3radical [36], and caus-ing NOS inactivation [37,38]. An alternative explan-ation for the lack of changes in nitrite under sepsis isthe presence of ... formation of O2–through the partial reduc-tion of oxygen by one electron. Subsequent reduction by one or two electrons can yield H2O2, and HO, respect-ively [46]. However, the main source of...