Tài liệu Báo cáo khoa học: Solution NMR structure of an immunodominant epitope of myelin basic protein Conformational dependence on environment of an intrinsically unstructured protein doc

... Journal compilation ª 2006 FEBS Solution NMR structure of an immunodominant epitope of myelin basic protein Conformational dependence on environment of an intrinsically unstructured protein Christophe ... (2004) Myelin basic protein – diverse conformational states of an intrinsically unstructured protein and its roles in myelin assem...

Ngày tải lên: 19/02/2014, 07:20

... explanation at atomic resolution. The con- formational analysis of different members of the polyene family is one important step essential in understanding their structure- to-activity relationships. ... [32] and candidin [33]. We took the advantage of the complete knowledge of the stereochemical information of these five polyene macrolides to study their conformation in solution,...

Ngày tải lên: 21/02/2014, 03:20

... between AB CDE FG HIJ Fig. 1. An overview of the new, refined models. Models A2bB3–bc (panels A and F), A2bB3-pec (panels B and G), A2bB3-ec (panels C and H), A2bB3-eotc (panels D and I) and A2bB3-eots (panels E and J), ... ribbons (protein only, panels A–E) and as surface (protein) and space-filling (carbohydrates and OG moieties) representations (panels F–J). The a IIb b 3 modules are i...

Ngày tải lên: 18/02/2014, 04:20

... Representation of the 3D structure of HtA in solution. (A) Superposition of the 20 best structures obtained in this work (PDB accession number 2kaa). (B) Ribbon representation of the lowest-energy con- former ... 85%, and they share a basic pI and common tertiary structure [4,13,14]. They fold into an a + b structure with a central five-stranded antiparallel b-sheet and an...

Ngày tải lên: 18/02/2014, 08:20

... connectivities, reported in Fig. 3A, and the analysis of the / and w angle distribution allowed the identification of the type and boundaries of the secondary structure elements. Crt consists of ... helix and strand b 1 and has its correspondent in Gly31, belonging to the loop that connects the a-helix to strand b 2 of AaHII. This can be Fig. 5. Solution structure of crotamin...

Ngày tải lên: 20/02/2014, 11:20

... data set consisting of 891 different NMR- derived distance and torsion angle restraints. Among the distance restraints, 447 intraresidual, 186 sequential, and 196 medium-range and long-range restraints ... wedge- shaped structure, composed of an antiparallel b-sheet on one face of the wedge and a three-turn a-helix with an antiparallel one-turn helix on the other face. It is t...

Ngày tải lên: 21/02/2014, 00:20

... cross-rotation and translation functions in the 10–4 A ˚ resolution range. The solution of the rotation function was used to perform the translation function calculations in both the P3 2 21 and P3 1 21 ... replacement and refined at a resolution of 2.0 A ˚ . The monomer present in the asymmetric unit contains 332 residues out of 336, one zinc ion, one DHAP molecule, one glyc- erol mol...

Ngày tải lên: 18/02/2014, 06:20

... toxicology of components of vegetation smoke. Rev Environ Contam Toxicol 119, 1–46. 6 Thornalley PJ (1996) Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic ... aspect of the protective function of MT is the scavenging of the acetaldehyde formed from ethanol and concomitant zinc release. Micromolar cellular concentrations of MT...

Ngày tải lên: 19/02/2014, 06:20

... and CcStP. We were interested to examine the r elative timing of steps involved in dimer formation and the appearance of oxyanion-dependent stabilization of activity during recon- stitution of ... molar c oncentration of enzyme active sites (based on the stoichiometry of PLP and enzyme subunit), K m is an apparent Michaelis constant, and [S] is the substrate concentration. Whe...

Ngày tải lên: 19/02/2014, 16:20

... polymerase and initiation of replication, e.g., a 3¢ terminal 98 nucleotide X-region of HCV [25,32], the secondary structure and the single-strand region a t the 3¢ end of BVDV 3¢ UTR [3], a nonbase-paired ... Expression and RdRp-TNTase assays of the full-length CSFV N S5B protein. ( A) The N S5B proteins o btained th ro ughout expression and extraction and purification were analyze...

Ngày tải lên: 19/02/2014, 16:20