Tài liệu Báo cáo khoa học: The role of antioxidants in the cytotoxicity of chemotherapeutic drugs pptx

... domain deletions are more com- mon at either of the protein termini, and that their occurrence is slightly higher at one of the termini, depending on the number of domains in the protein and the ... C−terminus Length of the N terminus in % of the deleted domain Length of the C terminus in % of the deleted domain Pfam, N−terminus Pfam, C −terminus Number...

Ngày tải lên: 19/02/2014, 07:20

... substrate carbinolamine intermediate; III, iminoquinone intermediate; IV, product Schiff base intermediate; V, aminoquinol intermediate. In the oxidative half-reaction the ami- noquinol intermediate ... substrates. The lack of inhibition observed with benzylamine (Fig. 5A) in comparison to the inhibition observed with tryptamine (Fig. 5B) suggests differences in binding of...

Ngày tải lên: 19/02/2014, 07:20

... at the internal site …PSNPflGPGP. The key properties of the preparation obtained were identical to those of native IF: the binding curves of vitamin B 12 to recombinant IF and gastric IF were the ... this Cbl binder hampers the uptake of the minute amounts of the vitamin present in food. Only around 1% of the ingested Cbl can be absorbed by passive diffusion [6]...

Ngày tải lên: 21/02/2014, 00:20

... biological activity of MIH and CHH during precisely timed stages of the moult cycle of Carcinus to determine changes in: (a) potency of these peptides in repressing ecdysteroid synthesis; (b) receptor ... level. In view of these observations, we also investigated levels of MIH and CHH peptides in the sinus gland and levels of transcripts in XO neurones during the...

Ngày tải lên: 21/02/2014, 00:20

... and mine it very deeply, not necessarily discovering every aspect of the domain but requiring that the various aspects be integrated with one another to produce a coherent whole. Even in the ... of our art? Instead of assuming that the problem is one of using typed English to access and/or update a file or files in a single database system, let us define a spectru...

Ngày tải lên: 21/02/2014, 20:20

... obese mice In order to gain insights into the potential biologically relevant role of miR-27 in the regulation of adipose tis- sue functions in vivo, we examined the expression of miR-27 in the genetically ... together, these results illustrate a critical and specific role of miR-27 in the regulation of adipogenic differentiation. miR-27 prevents the inducti...

Ngày tải lên: 18/02/2014, 08:20

... can therefore postulate that, when the segment beyond W140 was removed, the secondary structure of the protein disintegrated. Using the peak at 222 nm of the wild-type protein as an index of helical ... significant role in maintaining SNase tertiary structure. Our CD and DSC data show that the W140 in SNase is the amino acid responsible for the stability of the...

Ngày tải lên: 20/02/2014, 01:20

... thus blocking protein synthesis and leading cells to death. The current model proposed for the mechanism of antitumour action of BS-RNase is based on the ability of the protein to resist the neutralizing ... hypothesize that the cytotoxic activity of the latter monomers was due to the presence in these proteins of disulfide bonds, with their potential chemical insta...

Ngày tải lên: 20/02/2014, 11:20

... obtained by other groups who also point to the role of the connecting loop of the b-hairpin of defensins. A combination of mutational analysis [35] and structural analysis of the plant defensin Rs-AFP1 ... molecule comprising Ôresidues in the protruding domain consisting of the type VI b-turn and the first part of b-strand 3Õ (i.e. the b-hairpin loop and part...

Ngày tải lên: 20/02/2014, 11:20

... this protease at pH9 [10]. Further interest in the aromatic stacking is in the role of the electrostatic properties in enzymatic catalysis of API, and in distinguishing the functionally catalytic quadruple ... position. In the struc- tural deviation, the solvent ASA of the side-chain of His210 increased with the decrease in size of the side-chain at r...

Ngày tải lên: 21/02/2014, 03:20