Tài liệu Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model doc

... Fabry. (A, B) Heart – endothelial staining in Fabry mouse; (C, D) lung – epithelial cell staining increased in Fabry mouse; (E, F) brain micro- vascular endothelial staining in Fabry mouse. Magnification ... 2006 The Authors Journal compilation ª 2006 FEBS 2075 Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the AB...

Ngày tải lên: 19/02/2014, 07:20

... formal device of functional un- certainty, as defined by Kaplan and Zaenan [3] and Kaplan and Maxwell [2]. In this paper, we relate this characterization to that provided by Tree ~,djoining ... point of the paper. We note that, just as in a TAG, the elementary trees which are the domains of depen- dencies are available as a single unit during each step of...

Ngày tải lên: 21/02/2014, 20:20

... com- posed of an extracellular ligand-binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. The binding of a ligand to the extracel- lular domain of the EGFR induces ... However, the Akt pathway plays a minor role in the induction of apoptosis in intestinal epithelial cells. Instead, p38 MAPK phosphorylation is associated with mitoch...

Ngày tải lên: 16/02/2014, 09:20

... characterized and the most prominent path- ways are the extrinsic and intrinsic pathways. In the intrinsic pathway (also known as the ‘mitochondrial pathway’), apoptosis results from an intracellular ... understand the protec- tive effect of HSS against CCCP-induced apoptosis, the activation of caspase-3 was examined using the enzymatic Caspase-Glo 3 ⁄ 7 assay. After C...

Ngày tải lên: 16/02/2014, 09:20

... 5¢-GGAGATCTCCAGTGA TATCGACCA-3¢ and 5¢-ACGGCTTCTACGGATCGAA ACT-3¢ for PPARc ,5¢-AAGACAGCTCCTCCTCGAAGG TT-3¢ and 5¢-TGACCAAATCCCCATTTACGC-3¢ for aP2, 5¢-ATCCATGGATGGACGGTAACG-3¢ and 5¢-CTGGA TCCCAATACTTCGACCA-3¢ ... 5¢-GCGTCGGGTAGATCCAGTT-3¢ and 5¢-CTC AGTGGGGCTTAGCTCTG-3¢ for ACC, and 5¢-AACAC CCCAGCCATGTACGTAG-3¢ and 5¢-TGTCAAAGAAA GGGTGTAAAACGC-3¢ for b-actin. Expression levels...

Ngày tải lên: 16/02/2014, 09:20

... domains (a b-domain for the N-terminal cluster and an a- domain for the C-terminal cluster). In the absence of metals, apo-thionein (apo-T) is predominantly unstruc- tured and only upon metal ... cysteines and the absence of His and aromatic amino acids. MT3 contains 68 amino acids with 70% sequence identity to the MT1 and MT2 (MT1 ⁄ 2) isoforms. The MT3 sequenc...

Ngày tải lên: 16/02/2014, 15:20

... that this limitation is retreating, whereas the importance of accurate modeling and analy- sis approaches aiming at understanding the complex interactions in living cells is increasing. Materials ... enzymes and binding sites are often of the same order of magnitude. In all of these cases, the accuracy of Michaelis–Menten kinetics is unsatisfactory as a result of...

Ngày tải lên: 18/02/2014, 06:20

... stained at the base and at the tip, with overall very weak staining of the fused carpels. In the root, the central cylinder was stained, whereas the primary root tips and tips of emerging lateral ... motif was noted on the basis of homology with the C-terminal region of meprins A and B and the TRAF-C domain, and, like the BTB domain, facilitates protei...

Ngày tải lên: 18/02/2014, 06:20

... ‘Promotion of Fundamental Research in Health Science’ of the Organi- zation for Pharmaceutical Safety and Research. In May 2009, the FDA in the USA approved bevacizumab for the treatment of patients ... solafe- nib and sunitinib, which inhibit a variety of tyrosine kinases including VEGFRs, have been approved for the treatment of renal cell cancer and li...

Ngày tải lên: 18/02/2014, 11:20

... cellular ceramide are regulated by the de novo pathway and the recycling pathway. The former relates to the synthesis of ceramide through the conden- sation of palmitate and serine in a series of ... demon- strated that PLA2G6 plays a role in the ceramide pathway; activation of this enzyme promotes ceramide generation via neutral sphingomyelinase-ca...

Ngày tải lên: 18/02/2014, 14:20