Tài liệu Báo cáo khoa học: Final steps in the catabolism of nicotine Deamination versus demethylation of c-N-methylaminobutyrate doc

... to the complete mineraliza- tion of the pyrrolidine ring of nicotine, which after oxidation by 6-hydroxy-l -nicotine oxidase, is cleaved off from the pyridine ring of nicotine in the form of CH 3 -4-aminobutyrate. ... pyrrolidine moiety of nicotine. Expression of the genes of these enzymes was dependent on the presence of nicotine in the growth medium...

Ngày tải lên: 19/02/2014, 07:20

... at higher levels in testes than ovaries. The deep interest in Dmrt1 in the field of sex deter- mination in fish came with the discovery of a dmrt1 homologue on the Y chromosome of the fish medaka (Oryzias ... Dmrt1, the ancestor of Dmrt1bY, is one of the downstream effec- tors of Sry in the male pathway. In medaka, the duplicated copy of dmrt1 has acqu...

Ngày tải lên: 14/02/2014, 19:20

... presence of 20E, however, favors the formation of the AaEcR⁄ AaUSP heterodimer [13], indicating that the regulation of the activity of these proteins occurs through protein–pro- tein interactions, ... single protein. Interestingly, during the initial process of identifying the NR family members in the A. aegypti genome, we predicted two isoforms of AaFTZ-F1, differ...

Ngày tải lên: 18/02/2014, 13:20

... this overall value into its component kinetic steps. The findings of this study are therefore of interest to the protein design field in general, but also inform upon how to fast track the design of peptides ... interpretation in distinguish- ing interacting from noninteracting proteins. One Fig. 1. Schematics of library designs. The helical wheel diagram looks down the a...

Ngày tải lên: 18/02/2014, 13:20

... versa, indicating a mosaic structure of the chromosomes. A jump in the Àz 0 n curve indicates an increase of the G + C con- tent; whereas a drop down in the Àz 0 n curve indicates a decrease of the ... the upper panel shows the cumulative percentage of the values at or below each interval. The Y-axis in the lower panel shows the number of sequences scorin...

Ngày tải lên: 19/02/2014, 07:20

... investigate the develop- ment of neuropathology in SE [6]. Despite numerous studies clearly indicating the importance of enzyme activity in the epileptic phenomenon, the mechanisms by which these ... not die within 24 h of observation. Determination of lipid peroxidation and nitrite content For all of the experimental procedures, 10% (w ⁄ v) homo- genates of the ar...

Ngày tải lên: 19/02/2014, 16:20

... productive binding of steroid substrates: in the first, a (small) sub population of enzyme binds directly the steroid in the reactive conformation, with the remainder of the enzyme binding the unreactive conformation. ... unusual in having two histidine residues (rather than the His-Asn pair seen in OYE, MR and some of the other member proteins; Fig. 1B) in t...

Ngày tải lên: 20/02/2014, 02:21

... of the signaling event. In particular, the rapid degradation of signaling proteins by the protea- some ⁄ ubiquitin system appears to play an important role in the control of the duration of the ... h). Nevertheless, it could also be explained by changes in translation or maturation of the protein. An increase was also observed in the rate of degradation of...

Ngày tải lên: 20/02/2014, 03:20

... determined by incubating the diluted recombin- ant proteins in the standard reaction mixture in the presence of increasing concentrations of PP i (0.05–0.5 m M )at55°C. Data were fit to the appropriate ... may offer a useful target for studies into the mechanism of the development and molting process in the roundworms. Investigation into the effects of fluoride exp...

Ngày tải lên: 20/02/2014, 11:20

... and control of the underlying applica- tion. Figure 1 shows screen shots of the COMIC interface. There are four main phases in the demonstra- tor. First, the user specifies the shape of their own ... 2000a) theory of information structure and intonation is used to con- strain the choice of pitch accents and boundary tones for the speech synthesiser. 5 Speech Synthesis...

Ngày tải lên: 20/02/2014, 15:20