Tài liệu Báo cáo khoa học: Activation of the Torpedo nicotinic acetylcholine receptor The contribution of residues aArg55 and cGlu93 ppt

Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf

... 158(21) and 296(154) [14–17]. The high speciﬁc activity of theseFVIIa variants is presumably linked to a more stableburial of the N-terminus of the protease domain in the activation pocket of the activation ... vicinity of the S1 pocket [11,34], in the ﬁrst part of activation loop 3, and in the area of the TF-interactive helix and the 170 loop [8,35], areasthat are stabilized by TF [9,25,26]. The Lys341(192)–Gly342(193) ... cleavage of the scissile bond. This would affect FX and peptidehydrolysis similarly, supported by the similar decreasein the rate of cleavage of both types of substrates. The effect of the G372(223)A...

Tài liệu Báo cáo khoa học: Activation of the Torpedo nicotinic acetylcholine receptor The contribution of residues aArg55 and cGlu93 ppt

... 273 (2006) 960–970 ª 2006 The Authors Journal compilation ª 2006 FEBS Activation of the Torpedo nicotinic acetylcholine receptor The contribution of residues aArg55 and cGlu93 Ankur Kapur, Martin ... for dTC and ACh [17,22] while the W54 of the neuronal nicotinic a7 receptor has beenshown to contribute to the binding of agonists [23]. In the GABAA receptor, the F64L mutation of the a1subunit ... to receptor assembly and ⁄ or play a role in the conforma-tional changes that result in channel activation or receptor desensitization.In the case of the Torpedo nAChR, the importance of the...

Tài liệu Báo cáo khoa học: Erythrochelin – a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea docx

... composed of a hOrn and a haOrn moiety.Furthermore, a long-range1H–13C correlation wasdetected between the carbonyl carbon of the serine and the d-CH2 of the hOrn, which constitutes the DKP.Therefore, ... characterization of these compounds isgrowing and may result in the synthesis of speciﬁcinhibitors based on the structure of the pathogensiderophore [16].A promising approach for the isolation of secondarymetabolites, ... revealing solely the presence of Ser- and hOrn -residues (Fig. S11). LC-MS analysis of the derivatized hydrolysate compared to syntheticstandards indicated the presence of d-Ser, l-hOrn and d-hOrn...

Tài liệu Báo cáo khoa học: Hepatic stimulator substance mitigates hepatic cell injury through suppression of the mitochondrial permeability transition pdf

... lm) was thenadded to the mitochondria, and the CCCP-treated mito-chondria were incubated at 4 °C for 4 h. The mitochondrialsuspension was then centrifuged at 12 000 g for 5 min, and the resulting ... minimal.Morphological evidence of the antiapoptoticeffect of HSSAs shown in Fig. 2A,B, the treatment of cells with50 lm CCCP induced profound changes in the nuclearmorphology of hepatoma cells, with ... pattern. The maximal effects of CsA and NIM811 could beobtained.Effect of HSS on CCCP-induced apoptosisCaspase activation is a key step in DNA damage-induced apoptosis. To further understand the...

Tài liệu Báo cáo khoa học: Simpliﬁed yet highly accurate enzyme kinetics for cases of low substrate concentrations ppt

... differs from the QSSA manifoldbecause of the presence of the ﬁrst term in the right-hand side of Eqn (17). Instead, the ZDP conditions of higher orders are natural extensions of the QSSA: theyalso ... mathemati-cally the fact that the total concentration of each of the four proteins is conserved. In particular, they are:Table 1. The state variables of the original (O) and the ﬁnal (F) model.Compound ... Amsterdam, The Netherlands2 Modelling, Analysis and Simulation, Centrum Wiskunde & Informatica, Amsterdam, The Netherlands3 Korteweg–de Vries Instituut, University of Amsterdam, The Netherlands4...

Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt

... vascu-lar tissue of cotyledons and mature leaves, whereas, in the ﬂowers, the anthers, connectives and ﬁlaments and the base and tip of the stigmata were stained. Similarto BPM2, BPM3 and BPM5 promoter:GUS ... cotyledons and in the central cylinder of the root, but not in the lower parts of the hypocotyl (a). Rosette leaves werestained in the vascular tissue of the leaf blade, whereas the petiole and older ... leaves and in the anthers of dif-ferentiated ﬂowers. We also detected meagre expres-sion along the root, with most obvious stainingpresent at the lateral root primordia and the base of the lateral...

Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx

... metabolism.Levels of cellular ceramide are regulated by the de novo pathway and the recycling pathway. The formerrelates to the synthesis of ceramide through the conden-sation of palmitate and serine ... together datasuggesting that some of the genes involved in the genetics of Lewy body disease, have in common the fact that they impinge on ceramide metabolism. Oneshortfall of the present theory ... disease, and in particular, toconsider whether they inﬂuence the penetrance of the GBA mutations.AcknowledgementsThis research was supported in part by the IntramuralResearch Program of the National...

Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf

... processes in the cartilage [1]. There-fore, the metabolic and structural changes of chondro-cytes in the articular cartilage play a signiﬁcant role in the initiation and progression of the disease. ... on the role of proteasomeinhibition and TRAIL in osteoarthritic disease and chondrocyte apoptosis, and the hypoxic inhibition of cartilage and chondrocyte degeneration.ResultsMacroscopic and ... intracellularsignalling and thus in cell physiology and cellulardestruction. ROS are known to induce a wide range of responses, depending on cell type and levels of ROSwithin the cell [23,24]. The aims of this...

Tài liệu Báo cáo khoa học: Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics pdf

... a molecular mass of 16 309.7 Da, butthis matched none of the DNA-predicted proteins.MS ⁄ MS of these ions gave the C-terminal sequence of Fig. 5. These and all other peaks of that spectrum ... substitution;MS ⁄ MS will then show the substituent positions of dif-ferent isomers. A problem for MS ⁄ MS of either the peptides for the bottom-up approach or of the proteinsfor the top-down approach ... of the molecular ions of that product. The observed isotopic abun-dances give calculated best ﬁts for the average increases of 0.0,1.0, 1.8, 3.7 and 4.4 Da, respectively, in the masses of the...

Tài liệu Báo cáo khoa học: An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii pptx

... asstimulation of the proliferation of lymphocytes, activa-tion of CCK receptors stimulate production of inter-leukins and secretion of immunoglobulins on the mucosal surface of the intestine [49,50]. The ... (i.e. when the young has no immune system of its own), whenthere is a profound fall in the microbial ﬂora of the pouch [6]. Neither eugenin nor other low molecularmass components of the pouch ... while d and c cleavages are indicated on the spectrum. The data shown in Fig. 4 gives the sequence of eugenin except that it does not indicate the relative orientation of residues 6 and 7. The spec-trum...

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