Tài liệu Báo cáo khoa học: Activation of the Torpedo nicotinic acetylcholine receptor The contribution of residues aArg55 and cGlu93 ppt

... 158(21) and 296(154) [14–17]. The high specific activity of these FVIIa variants is presumably linked to a more stable burial of the N-terminus of the protease domain in the activation pocket of the activation ... vicinity of the S1 pocket [11,34], in the first part of activation loop 3, and in the area of the TF-interactive helix and the 170 loop [...

Ngày tải lên: 18/02/2014, 08:20

... 273 (2006) 960–970 ª 2006 The Authors Journal compilation ª 2006 FEBS Activation of the Torpedo nicotinic acetylcholine receptor The contribution of residues aArg55 and cGlu93 Ankur Kapur, Martin ... for dTC and ACh [17,22] while the W54 of the neuronal nicotinic a7 receptor has been shown to contribute to the binding of agonists [23]. In the GA...

Ngày tải lên: 19/02/2014, 07:20

... composed of a hOrn and a haOrn moiety. Furthermore, a long-range 1 H– 13 C correlation was detected between the carbonyl carbon of the serine and the d-CH 2 of the hOrn, which constitutes the DKP. Therefore, ... characterization of these compounds is growing and may result in the synthesis of specific inhibitors based on the structure of the pathogen sideropho...

Ngày tải lên: 16/02/2014, 09:20

... lm) was then added to the mitochondria, and the CCCP-treated mito- chondria were incubated at 4 °C for 4 h. The mitochondrial suspension was then centrifuged at 12 000 g for 5 min, and the resulting ... minimal. Morphological evidence of the antiapoptotic effect of HSS As shown in Fig. 2A,B, the treatment of cells with 50 lm CCCP induced profound changes in the nuclear...

Ngày tải lên: 16/02/2014, 09:20

... differs from the QSSA manifold because of the presence of the first term in the right- hand side of Eqn (17). Instead, the ZDP conditions of higher orders are natural extensions of the QSSA: they also ... mathemati- cally the fact that the total concentration of each of the four proteins is conserved. In particular, they are: Table 1. The state variables of...

Ngày tải lên: 18/02/2014, 06:20

... vascu- lar tissue of cotyledons and mature leaves, whereas, in the flowers, the anthers, connectives and filaments and the base and tip of the stigmata were stained. Similar to BPM2, BPM3 and BPM5 promoter:GUS ... cotyledons and in the central cylinder of the root, but not in the lower parts of the hypocotyl (a). Rosette leaves were stained in the vascular...

Ngày tải lên: 18/02/2014, 06:20

... metabolism. Levels of cellular ceramide are regulated by the de novo pathway and the recycling pathway. The former relates to the synthesis of ceramide through the conden- sation of palmitate and serine ... together data suggesting that some of the genes involved in the genetics of Lewy body disease, have in common the fact that they impinge on ceramide metabolis...

Ngày tải lên: 18/02/2014, 14:20

... processes in the cartilage [1]. There- fore, the metabolic and structural changes of chondro- cytes in the articular cartilage play a significant role in the initiation and progression of the disease. ... on the role of proteasome inhibition and TRAIL in osteoarthritic disease and chondrocyte apoptosis, and the hypoxic inhibition of cartilage and chondrocyte d...

Ngày tải lên: 18/02/2014, 14:20

... a molecular mass of 16 309.7 Da, but this matched none of the DNA-predicted proteins. MS ⁄ MS of these ions gave the C-terminal sequence of Fig. 5. These and all other peaks of that spectrum ... substitution; MS ⁄ MS will then show the substituent positions of dif- ferent isomers. A problem for MS ⁄ MS of either the peptides for the bottom-up approach or of the p...

Ngày tải lên: 18/02/2014, 16:20

... as stimulation of the proliferation of lymphocytes, activa- tion of CCK receptors stimulate production of inter- leukins and secretion of immunoglobulins on the mucosal surface of the intestine [49,50]. The ... (i.e. when the young has no immune system of its own), when there is a profound fall in the microbial flora of the pouch [6]. Neither eugenin nor other l...

Ngày tải lên: 19/02/2014, 16:20