Tài liệu Báo cáo khoa học: Effects of sequestration on signal transduction cascades docx

... investigated the effects of sequestration in a complex signal transduction cascade with negative feedback as described below. The effect of sequestration in MAPK signal transduction cascade The ... and MAPKK. Discussion The function of the signal transduction network is to sense changes in the environment of the organism in the form of signals of physicochemical...

Ngày tải lên: 19/02/2014, 07:20

... these ions on Ca 2+ -binding or calcium ion conduct- ing membrane proteins. Lanthanide ions were found to inhibit the twitch of toad skeletal muscle with effect- iveness depending on the ion radius. ... about the effect of the luminal (trans) calcium on the activity of the RyR1 are controversial depending on experimental conditions. Inhibition of the channel was described at h...

Ngày tải lên: 19/02/2014, 16:20

... a dual action, i.e. ADP-ribosyla- tion of EF-2 (inhibition of protein synthesis) and mitochondrial alteration (intrinsic apoptotic effect). Both pathways require the translocation of ETA into the ... cyto- solic EF-2 on the one hand, and the mitochondrial membrane on the other hand. However, the potential role (if any) of ADP-ribosylation of EF-2 in the mitochondrial apoptotic r...

Ngày tải lên: 18/02/2014, 04:20

... could reasonably be a reflection of lowered ATPase activity at low Ca 2+ concentrations [25]. Thus, the conformational change from the elevated conformation to the shorter conformation was dependent on ... fluctuation and shape changes correspond to the conformational changes (long-distance move- ment of the N-domain and rotational motion of the A-domain) of SERCA during the ATP-media...

Ngày tải lên: 14/02/2014, 14:20

... were decreased by depletion of KCs. Our findings suggest that ablation of KCs protects against hepatic drug-metabolizing dysfunction by modulation of the inflammatory response. Abbreviations ALT, alanine ... based on the findings of other investigators showing the destruction of KCs after the intravenous administra- tion of GdCl 3 [15]. Hardonk et al. [15] demonstrated that large K...

Ngày tải lên: 14/02/2014, 18:20

... the activation energy of 28 ± 3 kcalÆmol )1 observed for the P79S mutant tetramer formation is consistent with the contribution of one proline isomerization event, most likely the conversion of Pro74 ... (2000) Nucleated conformational conversion and the replica- tion of conformational information by a prion determi- nant. Science 289, 1317–1321. 99 Wood SJ, Wypych J, Steavenson S, Lo...

Ngày tải lên: 14/02/2014, 18:20

... the conversion of MPTP to MPP + is not required for aggregation of a-synuclein. MPP + was found to accelerate the rate of a-synuclein aggregation even in the absence of com- ponents of mitochondrial ... lm MPP + alone (0.103 h )1 ). The presence of dopamine, along with MPP + , results in a faster rate of formation of protofibrils (nucleation phase) and a slower rate of conver...

Ngày tải lên: 14/02/2014, 19:20

... Quantification of the contribution of various steps to the control of mitochondrial respira- tion. J Biol Chem, 257, 2754–2757. 46 Kholodenko BN (1984) Control of mitochondrial oxidative phosphorylation. ... mitochondria. Yet, in Table 2. Effect of CYPD ablation or its inhibition by cyclosporin A on the rates of respiration of mouse liver mitochondria. ACI, accep- tor control i...

Ngày tải lên: 14/02/2014, 19:20

... alteration of host-cell transcription signalling pathways. Another important consequence of phosphorylation- independent CagA interactions in polarized epithelial cells is the disruption of cell–cell ... successive events: the induction of cell scattering and cell elonga- tion. Although induction of early cell motility mainly depends on a CagA-independent T4SS factor [23], cell el...

Ngày tải lên: 14/02/2014, 19:20

... to varying concentrations of stea- rate (18:0), oleate (18:1), or mixtures of the two fatty acids, and the effects on cell proliferation, lipid droplet accumulation and induction of endoplasmic reticulum ... addition, phosphorylation of eIF2a, which is characteristic of PERK branch activa- tion of ER stress, has been demonstrated in humans with NAFLD and nonalcoholic steatohep...

Ngày tải lên: 14/02/2014, 22:20