Tài liệu Báo cáo khoa học: Aldehydes release zinc from proteins A pathway from oxidative stress⁄lipid peroxidation to cellular functions of zinc pptx

... Aldehydes release zinc from proteins. A pathway from oxidative stress ⁄ lipid peroxidation to cellular functions of zinc Qiang Hao and Wolfgang Maret Departments of Preventive Medicine & ... predominant mechanism of zinc release is the modification of the cysteine lig- ands of zinc. Aldehydes increase the concentration of available cellular...

Ngày tải lên: 19/02/2014, 06:20

... repression of aromatase transcription, a possible mechanism favoring the male pathway in tilapia. Endocrinology 151, 1331– 1340. 48 Nakamoto M, Wang DS, Suzuki A, Matsuda M, Nagahama Y & Shibata N ... Natl Acad Sci USA 99, 11778–11783. 9 Matsuda M, Nagahama Y, Shinomiya A, Sato T, Matsuda C, Kobayashi T, Morrey CE, Shibata N, Asakawa S, Shimizu N et al. (2002) DMY is a Y-spe- ci...

Ngày tải lên: 14/02/2014, 19:20

... cavity is comparable with that of adenine- lacking cobalamins, and thus allows the damaged cofactor to pass through it. Intact cofactor, an ade- nine-containing cobalamin, is not released from the enzyme ... number of reactivations per molecule of the reactivating factor was observed to be approximately two, at a molar ratio of the reacti- vating factor to the enzyme of 0....

Ngày tải lên: 15/02/2014, 01:20

... interaction to APC substrates FVa and FVIIIa also cannot be ruled out. The same reasoning can be applied when comparing membrane binding and anticoagulant activ- ity data of mutant V and mutant ... turning off the major driving force of coag- ulation. Although historically known for its role in anticoagulation, APC was recently revealed to have cytoprotective, anti-inflammatory and ant...

Ngày tải lên: 18/02/2014, 06:20

... activates adenylate cyclase (CyaA) and leads to an increase in the intra- cellular cyclic AMP (cAMP) level [1]. Mathematical models of catabolite repression in E. coli The (isolated) reactions of the ... intra- cellular metabolites. An approach that combines flux balance analysis (FBA) with an ordinary differential equation (o.d.e.) model of the slow time scales is called dynamic fl...

Ngày tải lên: 18/02/2014, 13:20

... cytoskeleton: a new view of palytoxin toxicity M. Carmen Louzao, Isabel R. Ares and Eva Cagide Departamento de Farmacologia, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo, Spain Introduction Palytoxin ... cells because of the intracellular Na + influx and membrane depolarization; and (c) an as yet unidentified pathway that is independent of changes in membrane p...

Ngày tải lên: 18/02/2014, 14:20

... S, Khachatr- yan A, Vyas S, Arrowsmith CH, Clarke S, Edwards A, Joachimiak A et al. (2001) Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase. Structure ... enterica Typhimurum strain IFO12529 genomic DNA as the template using Deep Vent DNA polymerase (New England Biolabs, Ipswich, MA, USA), a sense primer (CATATGGCTAGC ATGCGCATATTGCTG...

Ngày tải lên: 18/02/2014, 14:20

... at a scanning rate of 100 nmÆmin )1 , a time constant of 1 s, a bandwidth of 2 nm and a resolution of 0.5 nm. Both far- and near-UV spectra were measured at 20 °C and final spectra are an average ... k max data. Transition curves were analyzed according to a two-state model, as described in the previous section. Phase-diagram analysis of fluorescence data A novel, qualit...

Ngày tải lên: 18/02/2014, 17:20

... encoding potential enzymes into microorganisms such as bacteria, this process can be harnessed in the laboratory to concen- trate the selection process on an individual catalytic activity. A great advantage ... overall reaction [50]. A rationally designed variant of L -Ala- D / L -Glu epimerase (a third member of the enolase superfamily, Fig. 8), containing a mutation (D297G) an...

Ngày tải lên: 19/02/2014, 12:20

... k 5 x 6 ð22Þ In addition to referring to the a bsence of steady states on the border of t he phase space, the procedure b y Clarke [22] enables us to identify qualitatively phase trajectories that lead to a ... the kinetic parameters t hat enable such oscillations. The main result of such an analysis is that oscillations arise if t he parameter k 3 is the l argest and the pa...

Ngày tải lên: 19/02/2014, 16:20