Tài liệu Báo cáo khoa học: Steady-state kinetic behaviour of functioning-dependent structures docx

... investigate the sensitivity of the two-enzyme system to the different input variables and to explain the behaviour of the branch-point in terms of the kinetic properties of CGS and TS. Sensitivity ... independent of what happens on the cystathionine side. The Phser branch-point combines the divergence of two fluxes (fluxes of cystathionine and threonine) with the convergence...

Ngày tải lên: 20/02/2014, 02:21

... formation of the bicyclic penicillin nucleus; S. clavuli- gerus enzyme Swiss-Prot P10621). Understanding of the catalytic mechanism of DAOCS [9–11] has been advanced by a combination of biochemical and ... Mutation of R258 to glutamine results in loss of coupling between penicillin oxidation and 2-OG conver- sion [17]. Moreover, the activity of the R258Q mutant could be restored...

Ngày tải lên: 20/02/2014, 23:20

... of EM contain valuable information about the incor- rect biases of these models. However, EM is chang- ing hundreds of thousands of parameters at once in a non-trivial way, so we need a way of ... face of label symmetry and ran experiments exploring the effectiveness of EM as a function of the amount of data. Finally, we hope that setting up the general framework to understa...

Ngày tải lên: 20/02/2014, 09:20

... important but often ignored requirement of developmental compatibility. One of the most significant findings in child lan- guage research of the past decade is that different aspects of syntactic ... revises a set of syntactic_rules upon presentation of partially bracketed sentences. Note that however, the state of the learning sys- tem at any time is still a single set o...

Ngày tải lên: 20/02/2014, 19:20

... agent _of take put fred speech-action mental-action consistof hand foot source _of speech-action destination _of speech-action power human speed slow mass human Figure 2. Examples of ... than 90% of the questions [12]L In other terms, surface semantics seems to capture what, at first glance, a human reader understands of a piece of text. In[26] , the usefulness...

Ngày tải lên: 21/02/2014, 20:20

... the processing of apicoplast protein leader sequence. Inhibition of any of these activities could contribute to MA interference in the maturation of the parasite. Polypharmacology of MA The observed ... mixing 100 l L of 100 l m ZnSO 4 .H 2 O, 200 lL of 0.3 m Na 2 CO 3 pH 10, 10 lL of com- pound (MA or EDTA as control) and 6 lL of Eriochrome Black T (5 mgÆmL )1 in ethanol, p...

Ngày tải lên: 14/02/2014, 14:20

... Leu23 of the CT-extension of the rmErv-C +CT molecule with a minimum distance of 1.9 A ˚ between two atoms of the two leucines (Fig. 8A). Because the Leu23 residue of the CT-extension of the ... USA). Conditions for the measurement of the kinetic parameters of rproErv-C +CT are as described earlier [29]. K m and V max values of rproErv-C +CT were calculated by nonlinear fit...

Ngày tải lên: 14/02/2014, 14:20

... recruitment of MOF to recently transcribed regions, especially at the 3¢ ends of genes where H3-K36me3 is enriched [128]. In mammalian cells MOF also exists as part of a sepa- rate MOF–MSLv1 complex ... enrichment of AcH4-K16 within transcribed genes is closely correlated with binding of both MOF and Tip60 (equivalent to Esa1 in yeast NuA4) [124,130]. However, in human cells depleti...

Ngày tải lên: 14/02/2014, 18:20

... 2e – apoCox17 2S-S Cytoplasm IMS Matrix Fig. 5. Pathway of copper insertion into the Cu A site of COX in humans. The structures of Cox2 and of Cox17, Sco1 and Sco2 in their differ- ent metal or ... oxidoreductase function of the CXXXC motif of human Sco proteins could therefore be impli- cated not only in the maturation of the Cu A site of Cox2 but also in the maintenance o...

Ngày tải lên: 14/02/2014, 18:20

... Culture of Japan (G.T.); the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation Table 1. miRNAs involved in the feedback regulation of ... [7–10], few have focused upon the role of miRNAs in regulatory network of various cell signaling pathways. We summarize the current knowledge of the interdependence of miRNA...

Ngày tải lên: 14/02/2014, 19:20