Tài liệu Báo cáo khoa học: Interferon-a induces sensitization of cells to inhibition of protein synthesis by tumour necrosis factor-related apoptosis-inducing ligand ppt

... Co-transfection of DAT with empty vector served as a control for background sensitivity to DA toxicity in the absence of p25a. Displayed is the percentage survival of DA-treated cells relative to cells ... empty vector, DAT ⁄ P25a and DAT ⁄ a-syn to obtain equal concentrations of vector DNA were incubated in the absence and presence of 0.5 m M DA for 24 h and subjected to...

Ngày tải lên: 14/02/2014, 21:20

... derivative of this function. The flux rate of CO 2 into sucrose synthesis (r CO 2 !Suc ) was caclulated as the difference between the rate of net photosynthesis and that of net starch synthesis ... (unit: C 6 h )1 Æg )1 FW): r CO 2 !Suc ¼ r NetPhotosynthesis Àr CO 2 !Starch Ratesof net photosynthesis (r NetPhotosynthesis ) were calcu- lated as the average rate of carbon uptake du...

Ngày tải lên: 14/02/2014, 22:20

... expression of inflammatory cytokines (tumor necrosis factor-a, inter- leukin-6 and interleukin-1b) was increased in the adi- pose tissue of ANGPTL2 transgenic mice compared with that of wild-type ... development of inflamma- tion and increased risk of atherosclerosis [21], focal ANGPTL2 secreted by vascular endothelial cells may be a mediator linking smoking to cardiovascular...

Ngày tải lên: 14/02/2014, 22:20

... beginning to provide a picture of how these domains are used to regulate the targeting, assembly and enzymatic activity of MLL1 complexes. The MLL protein The MLL1 gene encodes a large protein of 3969 ... portion of the MLL1 TAD bound to the KIX domain of the cAMP response element-binding (CREB) binding protein (CBP) [23], a peptide from the Win motif of MLL1 bound to...

Ngày tải lên: 16/02/2014, 14:20

... Triton X-100 and 2-propylphenol [3,38]. To study the effect of inhibitors of substrate binding on the reductive activity of PDI, the precipitation of insulin was followed in the presence of PDI ... usu- ally considered to be a specific inhibitor of PDI activ- ity [6–8]. However, in vitro evidence for the action of bacitracin as an inhibitor of PDI is scarce, and evi- dence...

Ngày tải lên: 16/02/2014, 14:20

... the loss of a specific neuroinhibitory factor, rather than the presence of a neurotrophic fac- tor. This factor was later isolated and identified as GIF, its name derived from its ability to significantly impair ... consistent reports of neuronal synthesis of GIF, albeit at seem- ingly much lower levels than within astrocytes. Neuro- nal synthesis of GIF is highly localized to...

Ngày tải lên: 16/02/2014, 15:20

... flexible programmatic access to the data, allowing users to write clients to customize and automate access directly from their simulation software, systems biology platforms, tools or databases [25]. ... developed to advise on the mini- mum requirements to follow in the storage and dis- semination of experimental data in fields such as transcriptomics and proteomics, which will ulti...

Ngày tải lên: 18/02/2014, 04:20

... the mechanisms of endopeptidase activ- ity, nor the inhibition of the enzyme by their endoge- nous protein inhibitors cystatins and stefins [21]. A further step in understanding of these mechanisms was ... pairs of superimposed CA atoms of cathepsin B molecules, excluding residues 105–125 of the occluding loop, is 0.34 A ˚ , whereas the r.m.s.d. between all pairs of superim...

Ngày tải lên: 18/02/2014, 04:20

... promotes the stability of hMS by facilitating uptake of cobalamin by the apo-form of hMS [14]. The enhanced cofactor binding is thought to result from MSR-catalysed reduction of exogenous aquacob(III)alamin ... the activity of hMS was found to be less than in the absence of any flavoprotein, which may be attributed to a tendency of oxidized MSR to withdraw reducing eq...

Ngày tải lên: 18/02/2014, 08:20

... available: Fig. S1. MS spectrum of protein 9, fraction 1. Fig. S2. MS spectrum of protein 12, fraction 1. Fig. S3. MS spectrum of protein 14, fraction 1. Fig. S4. MS spectrum of protein 2, fraction 5 ⁄ ... spectrum of protein 4, fraction 5 ⁄ fraction 6. Fig. S6. MS spectrum of protein 5, fraction 5 ⁄ fraction 6. Fig. S7. MS spectrum of protein 8, fraction 5 ⁄ fract...

Ngày tải lên: 18/02/2014, 08:20