Tài liệu Báo cáo khoa học: Multiple promoters regulate tissue-speciﬁc alternative splicing of the human kallikrein gene, KLK11⁄hippostasin ppt

... Multiple promoters regulate tissue-speciﬁc alternative splicing of the human kallikrein gene, KLK11⁄hippostasinShinichi Mitsui1,*, Terukazu ... pro-moter use of the KLK11 gene appears to link to the splicing pathway of KLK11 mRNAs and to regulate the trafﬁcking of KLK11 isoforms in the trans-Golginetwork. Such complex regulation of KLK11 ... encoded another type of KLK11, isoform 2,despite the presence of exon 1c. The secretory path-ways of KLK11 isoforms appeared to differ, althoughboth isoforms were secreted from cells. Hence, the...

Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx

... counter. Values are the mean of six replicates. The speciﬁc uptake was determined bysubtracting the uptake counts in the absence of inhibitorfrom the uptake counts in the presence of cocaine or S-cita-lopram, ... of 200 lL of complete cell culture medium. After 48 h, the cells were incubated in the absence or presence of 0.5 mmDA. After 24 h of incubation at 37 °C, 5% CO2, the med-ium containing the ... Co-expression of p25aand the dopamine transporter in HEK-293-MSR cells sensitized them to the toxicity of extracellular dopamine. Neuronal expression of p25a thusholds the potential to sensitize the...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt

... observation). In the ternarycomplex, the histone H3 peptide binds in a deep chan-nel that divides a pair of acidic lobes, one of which iscomposed of residues from the SET-I region and the other of residues ... present. This is because the con-struct used to determine the structure of the MLL1SET domain lacks the evolutionarily conserved Winmotif in the region ﬂanking the N-terminus of the SETdomain [26], ... (green) bound to the central opening of WDR5 (PDB code3EG6). The position of the conserved Arg 3765 is indicated. On the left, a stick representation is used to show the position of the MLL1Win...

Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf

... in all of these conditions [22]. In the trau-matically injured brain, however, the synthesis of MT1and MT2, as well as the synthesis of GIF, are up-regu-lated by reactive astrocytes in the vicinity ... ﬁneprocesses of these cells. Astrocytic synthesis of GIFis mainly found in the cortex, brainstem and spinalcord [6].Additionally however, there are also consistentreports of neuronal synthesis of GIF, ... partly explaining the vast neuronal lossin the AD brain. Further investigation of the increasedneurotrophic activity of the AD brain revealed that itcorrelated with the loss of a speciﬁc neuroinhibitoryfactor,...

Tài liệu Báo cáo khoa học: Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver pptx

... [6] and inhibits the tyrosine kinase activity of the IR [7]. On the basis of the crystal structure of the tyrosine kinase domain of the IR in complex with the PIR ⁄ BPS domain of Grb14,Depetris ... we cannot assess whether the kinase activity of the IRs before KCl treatment repre-sents residual activity of receptors with Grb14 bound tothem, the activity of a fraction of receptors lackingbound ... interaction of Grb14 with the IR is probably the major determi-nant of the insulin-induced membrane translocation of Grb14, several lines of evidence suggest that the associ-ation of Grb14 via...

Tài liệu Báo cáo khóa học: Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation 2 process of onconase pdf

... described in the Materials and methods. Completion of the hydrolysis wasconﬁrmed by the disappearance of the (Met1)-ONC(M23L) signal in the MALDI-TOF mass spectra 1 h after the addition of AAP. The ... calculating the slope of the curves of Pyr-ONC (M23L) vs. time. From the rates of cyclizationshowninTable1,itcanbeinferredthattheformation of the N-terminal pyroglutamyl is not dependenton pH in the ... hydrogen bonded to the e-amino group of the Lys9 side-chain, which simultaneouslyinteracts with the main phosphate of the substrate [32]. The closer positioning of the N-terminus to the mainprotein...

Tài liệu Báo cáo khoa học: "Multiple Default Inheritance in a Unification-Based" pdf

... The former of these unifies the variable Prefix with either the empty string (in the case of tensed 'inverted' verbs) or the value of morph : prefix (for other variants), while the ... prefix and stem. The classes weg and vet set the value of the morph:prefix path of the verb (overriding the value given in the main set of verb), and specify in- heritance from the separable ... as its superelass extension a set of FSs, each member of which is input to the remainder of C, (c~+l, c,). The global exten- sion of L is then the yield of the most general class in its CPL...

Tài liệu Báo cáo khoa học: Multiple enzymic activities of human milk lactoferrin ppt

... the function of human cells. The discovery of ﬁveenzymatically distinct forms of LF, their cytotoxicity, and the ability of some of them to induce tumor cell apoptosisshould contribute to the ... Thedatashowtherelativeactivity of diﬀerent subfractions of LF from the milk of one donor (Fig. 2) and the range of variation in the relative activities of LF subfractionspuriﬁed from milk of ... reportedisoforms [9], one of which is LF RNase, further isoforms of this protein exist that possess other enzyme activities. The nature of the structural variations that give rise to theseFig.4.EnzymeactivitiesofLFrecoveredbygelﬁltrationonaTSKHW-55...

Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx

... we focus on the roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obes-ity and related metabolic diseases, and discuss whetherthese ANGPTLs could be targets for the preventionand treatment of these conditions.Suppression ... adiposetissue of ANGPTL2 null mice compared with that of wild-type mice [15]. These results raise the possibilitythat blocking ANGPTL2 signaling simultaneously sup-presses the expression of other inﬂammatory ... it is predicted that the suppression of ANGPTL2 signaling has few sideeffects. Therefore, for these reasons, we consider that the suppression of ANGPTL2 signaling as a therapeu-tic strategy...

Tài liệu Báo cáo khoa học : Chủ tịch Hồ Chí Minh và bản di chúc hôm nay và mai sau ppt

... ngQdi, Hd Chf Minh cdn mang theo khat vgng ve mdt da't nQde Viet Nam dde lap, hoa binh, thd'ng nhat, dan chu va giau manh, cung mdt the gidi hanh phuc eho eon ngQdi. ... chuong hoa binh va cdng ly, nhan dan tien bd the gidi la anh em eua nhau: "Tat ca nhQng ngQdi ed iQOng tri tren the gidi deu nhin thay d Nguyen Ai Qud'c ... dQdng, hoac la nan nhan eua che do cu. Bdi theo NgQdi, du la ai, hg cung mang ddng mau Viet, cung cd ngudn cdi, nen lay Idng nhan, khoan dung do iQOng, hQdng ve le phai chan...

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