Tài liệu Báo cáo khoa học: Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11⁄hippostasin ppt

... Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11 ⁄ hippostasin Shinichi Mitsui 1, *, Terukazu ... pro- moter use of the KLK11 gene appears to link to the splicing pathway of KLK11 mRNAs and to regulate the trafficking of KLK11 isoforms in the trans-Golgi network. Such complex regulation of KLK11 ... en...

Ngày tải lên: 19/02/2014, 06:20

... counter. Values are the mean of six replicates. The specific uptake was determined by subtracting the uptake counts in the absence of inhibitor from the uptake counts in the presence of cocaine or S-cita- lopram, ... of 200 lL of complete cell culture medium. After 48 h, the cells were incubated in the absence or presence of 0.5 mm DA. After 24 h of incubation at...

Ngày tải lên: 14/02/2014, 21:20

... observation). In the ternary complex, the histone H3 peptide binds in a deep chan- nel that divides a pair of acidic lobes, one of which is composed of residues from the SET-I region and the other of residues ... present. This is because the con- struct used to determine the structure of the MLL1 SET domain lacks the evolutionarily conserved Win motif in the region...

Ngày tải lên: 16/02/2014, 14:20

... in all of these conditions [22]. In the trau- matically injured brain, however, the synthesis of MT1 and MT2, as well as the synthesis of GIF, are up-regu- lated by reactive astrocytes in the vicinity ... fine processes of these cells. Astrocytic synthesis of GIF is mainly found in the cortex, brainstem and spinal cord [6]. Additionally however, there are also consistent re...

Ngày tải lên: 16/02/2014, 15:20

... [6] and inhibits the tyrosine kinase activity of the IR [7]. On the basis of the crystal structure of the tyrosine kinase domain of the IR in complex with the PIR ⁄ BPS domain of Grb14, Depetris ... we cannot assess whether the kinase activity of the IRs before KCl treatment repre- sents residual activity of receptors with Grb14 bound to them, the activity o...

Ngày tải lên: 18/02/2014, 18:20

... described in the Materials and methods. Completion of the hydrolysis was confirmed by the disappearance of the (Met1)-ONC (M23L) signal in the MALDI-TOF mass spectra 1 h after the addition of AAP. The ... calculating the slope of the curves of Pyr-ONC (M23L) vs. time. From the rates of cyclizationshowninTable1,itcanbeinferredthatthe formation of the N-termin...

Ngày tải lên: 19/02/2014, 12:20

... The former of these unifies the variable Prefix with either the empty string (in the case of tensed 'inverted' verbs) or the value of morph : prefix (for other variants), while the ... prefix and stem. The classes weg and vet set the value of the morph:prefix path of the verb (overriding the value given in the main set of verb), and specify in...

Ngày tải lên: 20/02/2014, 21:20

... the function of human cells. The discovery of five enzymatically distinct forms of LF, their cytotoxicity, and the ability of some of them to induce tumor cell apoptosis should contribute to the ... Thedatashowtherelative activity of different subfractions of LF from the milk of one donor (Fig. 2) and the range of variation in the relative activities of LF su...

Ngày tải lên: 21/02/2014, 00:20

... we focus on the roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obes- ity and related metabolic diseases, and discuss whether these ANGPTLs could be targets for the prevention and treatment of these conditions. Suppression ... adipose tissue of ANGPTL2 null mice compared with that of wild-type mice [15]. These results raise the possibility that blocking ANGPTL2 signaling simultaneously su...

Ngày tải lên: 14/02/2014, 22:20

... ngQdi, Hd Chf Minh cdn mang theo khat vgng ve mdt da't nQde Viet Nam dde lap, hoa binh, thd'ng nhat, dan chu va giau manh, cung mdt the gidi hanh phuc eho eon ngQdi. ... chuong hoa binh va cdng ly, nhan dan tien bd the gidi la anh em eua nhau: "Tat ca nhQng ngQdi ed iQOng tri tren the gidi deu nhin thay d Nguyen Ai Qud'c...

Ngày tải lên: 17/02/2014, 05:20